The Effect of Epidural Anesthesia on the Optic Nerve Sheath Diameter in Preeclampsia
- Conditions
- Preeclampsia
- Interventions
- Procedure: Epidural anesthesia
- Registration Number
- NCT04095832
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
This study aims to assess the effect of epidural anesthesia on the optic nerve sheath diameter in parturients with preeclampsia.
- Detailed Description
This prospective observational study will be performed in parturients, either with or without preeclampsia, who scheduled to undergo elective cesarean delivery under epidural anesthesia. Epidural anesthesia will be done according to the standard technique. Optic nerve sheath diameter (ONSD) will be measured before and after the epidural injection of anesthetic solutions using ultrasonography. The investigators will assess whether epidural anesthesia has effect on optic nerve sheath diameter of pregnant women, and the investigators will also compare ONSD between healthy parturients and parturients with preeclampsia. The investigators will evaluate the relationship between ONSD and disease severity of preeclampsia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 22
- Patients scheduled to undergo planned cesarean section under epidural anesthesia if they have a singleton pregnancy, complicated by severe preeclampsia.
Severe preeclampsia was defined using the American College of Obstetricians and Gynecologist Task Force on Hypertension in Pregnancy recommendations
- Controls will be healthy pregnant women at term (>37 weeks), with a singleton pregnancy, no signs or symptoms of preeclampsia and no intrauterine fetal growth restriction, who are planned to undergo elective cesarean delivery under epidural anesthesia
- Contraindication to epidural anesthesia
- Morbid cardiovascular disease
- Cerebrovascular disease
- Known fetal anomaly
- Any signs of onset of labor
- Body weight < 40 kg or body weight > 100 kg
- Height < 140cm or height > 190cm
- eye disease
- infection or trauma near the eyes
- abnormality of intracranial pressure due to Intracranial pathology
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Parturients with preeclampsia Epidural anesthesia Parturients who were diagnosed with preeclampsia Healthy parturients Epidural anesthesia Healthy full-term parturients
- Primary Outcome Measures
Name Time Method Optic nerve sheath diameter (ONSD) after epidural anesthesia 3 minutes after the completion of epidural injection of the anesthetic solutions measured by transocular ultrasonography
- Secondary Outcome Measures
Name Time Method eclampsia during the admission period The occurrence of seizure during the admission period
intracranial hemorrhage during the admission period The occurrence of intracranial hemorrhage during the admission period
Umbilical arterial PO2 immediately after delivery PO2 in mmHg, Umbilical arterial blood gas analysis
Epigastric pain during the admission period The occurrence of epigastric pain during the admission period
Serum creatinine during the admission period Serum creatinine concentration
Apgar Score of fetus at 1 min, 5 min Apgar Score of delivered fetus
ALT during the admission period ALT measured during the admission period
Optic nerve sheath diameter (ONSD) before epidural anesthesia, 10, 20 minutes after the completion of epidural injection of the anesthetic solutions, 10 minutes after delivery of fetus, at the end of surgery. measured by transocular ultrasonography
Blood pressure on delivery day blood pressure in mmHg
Proteinuria during the admission period The presence of Proteinuria during the admission period
Headache during the admission period The occurrence of Headache during the admission period
Visual disturbances during the admission period The occurrence of Visual disturbances during the admission period
Oliguria during the admission period The occurrence of Oliguria during the admission period
Serum albumin during the admission period Serum albumin concentration
Platelet count during the admission period Platelet count measured during the admission period
AST during the admission period AST measured during the admission period
Umbilical arterial pH immediately after delivery pH in mmol/L, Umbilical arterial blood gas analysis
Umbilical arterial PCO2 immediately after delivery PCO2 in mmHg, Umbilical arterial blood gas analysis
Umbilical arterial base excess immediately after delivery base excess in mmol/L, Umbilical arterial blood gas analysis
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of