The Effect of 10-Week Exercise Training on Children With Asthma

Not Applicable

Withdrawn

• Conditions: Asthma in Children
• Interventions: Other: Exercise Training

• Registration Number: NCT03716219
• Lead Sponsor: University of California, Irvine

Brief Summary

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10-10
• Primary Completion: 2013-10-10
• Study Completion: 2013-10-10
• Study First Submitted: 2018-10-03
• Study First Submitted QC: 2018-10-19
• Study First Posted: 2018-10-23
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-09
• Last Update Posted: 2021-02-12

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Good health
• Physical activity
• No evidence of disease or disability
• Diagnosed with persistent asthma (asthma subjects)
• BMI<95 percentile

Exclusion Criteria

• Use of illegal drugs or alcohol
• Very high physical fitness
• Pregnancy
• More than two asthma attack per week (asthma subjects)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Subjects with Asthma	Exercise Training	Subjects with asthma who received exercise training
Healthy Subjects	Exercise Training	Healthy control group which received the same exercise training intervention as the experimental group

Primary Outcome Measures

Name	Time	Method
Gene and microRNA expression will be compared between healthy and asthmatic subjects	12 weeks	Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls

Secondary Outcome Measures

Name	Time	Method
Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups	12 weeks	Absolute values of cytokines, growth hormones, and other biomarkers will be measured by flow cytometry and statistically analyzed.

Trial Locations

Locations (1)

Pediatric Exercise and Genomics Research Center, University of California, Irvine; 🇺🇸 Irvine, California, United States