Comparative evaluation of 5 percent Melatonin gel in combination with Platelet rich Fibrin and Platelet Rich Fibrin alone in the treatment of Intrabony defects: A Clinico-Radiographic Study.

Comparative evaluation of 5% Melatonin gel in combination with Platelet rich Fibrin and Platelet Rich Fibrin alone in the treatment of Intrabony defects: A Clinico-Radiographic Study.

Periodontitis is a chronic as well as multifactorial disease and if it left untreated then there are higher chances of destruction of periodontal apparatus which include, cementum, periodontal ligament and alveolar bone as a sequel of subgingival plaque accumulation which leads to inflammatory condition, caused by microbial infection and unbalanced host immune responses.

Melatonin has been reported to promote osteoblastic differentiation and formation of a bone. Melatonin accelerates the synthesis of type I collagen fibers in human osteoblasts. It also improves the gene expression of bone sialoprotein, alkaline phosphatase, osteopontin, and osteocalcin in preosteoblasts.

Choukroun et al described that platelet-rich fibrin (PRF), is a second-generation platelet concentrate incorporates platelets and growth factors within fibrin membranes.

Previously very few evaluations were studied to detect 5% Melatonin gel in combination of PRF and PRF alone in the treatments of intrabony defects by Cone Beam Computed Tomography (CBCT). So this study is designed to evaluate and compare the efficacy of 5% Melatonin gel in combination with PRF and PRF alone in the amount of bone fill obtaining as a treatment modality in intrabony defects in Periodontitis by CBCT.