S9624 Ifosfamide in Treating Patients With Meningeal Tumors

Phase 2

Terminated

• Conditions: Adult Rhabdomyosarcoma; Adult Brain Malignant Hemangiopericytoma; Adult Malignant Meningioma; Chondrosarcoma; Adult Fibrosarcoma; Adult Leiomyosarcoma
• Interventions: Drug: ifosfamide

• Registration Number: NCT00003292
• Lead Sponsor: SWOG Cancer Research Network

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of ifosfamide in treating patients with meningeal tumors that have recurred or that cannot be removed surgically.

Detailed Description

OBJECTIVES:

* Estimate failure free survival, overall survival, and response in patients with residual or recurrent/progressive aggressive meningeal tumors (malignant meningioma, hemangiopericytoma, and primary nervous system sarcoma) treated with ifosfamide.

* Evaluate toxicities of ifosfamide in this patient population.

OUTLINE: All patients receive ifosfamide IV continuously over 72 hours on days 1-3 of each 21 day treatment course. Patients are evaluated for response/progression after every 2 courses. Patients with stable disease receive up to 8 courses of therapy. Treatment continues in the absence of disease progression or unacceptable toxicity.

Patients are followed every 3 months for 1 year, then every 6 months thereafter.

PROJECTED ACCRUAL: Approximately 35 patients will be accrued for this study.

Study Timeline

• Study Start: 1998-07
• Study First Submitted: 1999-11-01
• Study First Submitted QC: 2003-01-26
• Study First Posted: 2003-01-27
• Primary Completion: 2004-01
• Study Completion: 2004-01
• Status Verified: 2013-11
• Last Update Submitted: 2013-11-07
• Last Update Posted: 2013-11-08

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ifosfamide	ifosfamide	ifosfamide

Trial Locations

Locations (70)

CCOP - Scottsdale Oncology Program; 🇺🇸 Scottsdale, Arizona, United States

City of Hope Comprehensive Cancer Center; 🇺🇸 Duarte, California, United States

Veterans Affairs Medical Center - Palo Alto; 🇺🇸 Palo Alto, California, United States

Stanford University Medical Center; 🇺🇸 Stanford, California, United States

CCOP - Colorado Cancer Research Program, Incorporated; 🇺🇸 Denver, Colorado, United States

CCOP - Christiana Care Health Services; 🇺🇸 Newark, Delaware, United States

Veterans Affairs Medical Center - Gainesville; 🇺🇸 Gainesville, Florida, United States

H. Lee Moffitt Cancer Center and Research Institute; 🇺🇸 Tampa, Florida, United States

Veterans Affairs Medical Center - Tampa (Haley); 🇺🇸 Tampa, Florida, United States

Emory University Hospital - Atlanta; 🇺🇸 Atlanta, Georgia, United States

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