Laser Therapy on Orthodontic Tooth Movement

Not Applicable

Completed

• Conditions: Laser Therapy; Orthodontic Tooth Movement; Bone Remodeling
• Interventions: Procedure: Orthodontic force; Device: Low-level Laser Therapy

• Registration Number: NCT04070170
• Lead Sponsor: Ildeu Andrade Jr.

Brief Summary

The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic tooth movement (OTM) on human subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-02-01
• Primary Completion: 2018-11-06
• Study First Submitted: 2019-08-15
• Study First Submitted QC: 2019-08-24
• Study First Posted: 2019-08-28
• Study Completion: 2019-09-16
• Status Verified: 2020-09
• Disposition First Submitted: 2020-09-15
• Disposition First Submitted QC: 2020-09-16
• Last Update Submitted: 2020-09-16
• Disposition First Posted: 2020-09-24
• Last Update Posted: 2020-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Facial convexity
• Protrusion or biprotrusion of the incisors
• Dental crowding
• Healthy periodontal condition
• Satisfactory oral hygiene

Exclusion Criteria

• Patients under medications that may interfere with bone metabolism, such as anti-inflammatory, antibiotics and hormonal supplements in the previous three months
• Skeletal crossbite
• Parafunctional habits
• Occlusal interference

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Orthodontic force only	Orthodontic force	Orthodontic force is applied and the premolars is extracted after 24 hours, with no laser therapy
Low-level laser therapy and no orthodontic force	Low-level Laser Therapy	No orthodontic force. Laser is applied on the first day and the premolars is extracted after 24 hours
Low-level laser therapy and application of orthodontic force	Low-level Laser Therapy	Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours
Low-level laser therapy and application of orthodontic force	Orthodontic force	Orthodontic force and Laser is applied on the first day and the premolars is extracted after 24 hours
Low-level laser therapy and orthodontic force	Low-level Laser Therapy	Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated
Low-level laser therapy and orthodontic force	Orthodontic force	Orthodontic force and Laser is applied and the orthodontic tooth movement is evaluated
Orthodontic force with no laser therapy	Orthodontic force	Orthodontic force is applied and the orthodontic tooth movement is evaluated, with no laser therapy

Primary Outcome Measures

Name	Time	Method
Rate of orthodontic tooth movement, with and without low-level laser therapy	The quantification of OTM was performed after 3 months of canine retraction	The canine retraction was measured with a digital dynamometer

Secondary Outcome Measures

Name	Time	Method
Chemokine levels in the periodontal tissue after LLLT and orthodontic force	The chemokine levels were assayed on days 0, 1, 7 and 14 after application of orthodontic force and low-level laser therapy	The chemokine levels were measured in the periodontal tissue after LLLT and orthodontic force by means of a cytometric bead array (CBA)

Trial Locations

Locations (1)

Pontifical Catholic University of Minas Gerais; 🇧🇷 Belo Horizonte, MG, Brazil