Evaluation Study of Medical-Social Collaboration Model for Middle-aged and Older Adults With Depressive Symptoms

Not Applicable

Recruiting

• Conditions: Depression

• Registration Number: NCT07064551
• Lead Sponsor: The University of Hong Kong

Brief Summary

The goal of this clinical trial is to learn if a medical-social collaboration model works to reduce depressive symptoms in middle-aged and older adults with subsyndromal depressive symptoms who are waiting for their first psychiatric appointment. Secondary outcomes of the study include reduced anxiety symptoms, reduced loneliness, reduced rumination, reduced self-criticism, improved self-reassurance, improved resilience, improved self-efficacy, improved health-related quality of life, as well as improved quality-adjusted life years, and reduced healthcare service utilisation.

Researchers will compare a medical-social collaboration model to a self-management booklet.

Participants will:

* Receive CBT-based stepped-care interventions through the medical-social collaboration model or a self-management booklet.

* Complete a survey about their mental health and service use every three months until their first psychiatric appointment.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-07
• Study First Submitted: 2025-07-11
• Study First Submitted QC: 2025-07-11
• Study First Posted: 2025-07-14
• Last Update Submitted: 2025-07-14
• Last Update Posted: 2025-07-17
• Study Start: 2025-08-01
• Primary Completion: 2027-06
• Study Completion: 2027-06-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 192

Inclusion Criteria

• Currently awaiting psychiatric services provided by the Hospital Authority
• Have depressive symptoms of at least mild severity
• Able to provide informed consent

Exclusion Criteria

• A known history of autism spectrum disorder, intellectual disability, schizophrenia-spectrum disorder, bipolar disorder, Parkinson's disease, or dementia
• Imminent suicidal risk (temporary exclusion)
• Communication difficulties that preclude participation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in Depressive Symptoms	Baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months	Patient Health Questionnaire-9 (PHQ-9); range 0-27; higher scores indicate higher levels of depressive symptoms (worse outcome)

Secondary Outcome Measures

Name	Time	Method
Changes in Anxiety Symptoms	Baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months	Generalized Anxiety Disorder 2-item scale (GAD-2); range 0-6; higher scores indicate higher levels of anxiety symptoms (worse outcome)
Changes in Loneliness	Baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months	UCLA Loneliness Scale (UCLA-3); range 0-9; higher scores indicate higher levels of perceived loneliness (worse outcome)
Changes in Health Service Use	Baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months	Self-reported use of mental health services and medication in the past three months.; Service data from Hospital Authority, covering information on outpatient visits, hospitalisation days, Accident and Emergency service utilisation, types of medications and operations, and any other major cost items that may be affected by depression with cost implications.
Changes in Health-Related Quality of Life	Baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 21 months	EQ-5D-5L; range 0-1; higher scores indicate higher levels of health-related quality of life (better outcome)

Trial Locations

Locations (1)

The University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong