A randomised controlled trial of the combined use of paracetamol and ibuprofen to treat febrile childre
- Conditions
- FeverSigns and Symptoms
- Registration Number
- ISRCTN21521538
- Lead Sponsor
- Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Children presenting in the BRI children's emergency department with fever.
1. Age 6 months - 16 years
2. Children with a temperature of 38.0 degrees C or more will be eligible
1. Those admitted directly to resuscitation by ambulance or those transferred there following initial clinical assessment
2. Those eligible for recruitment in any other study running concurrently or those who have been recruited to a simultaneous study of children's fever
3. Prior administration that will interfere with randomisation: paracetamol within the last six hours or ibuprofen within the last six hours
4. Allergy to either study drug
5. Likely dehydration, cellulitis or skin infection, concomitant warfarin or heparin, chronic illness likely to interfere with drug metabolism (kidney or liver disease), immunosuppression, HIV+, concomitant chemo or radiotherapy, organ or bone marrow transplant recipient, immunosuppressive therapy in the last three months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The child's temperature one hour after study antipyretics
- Secondary Outcome Measures
Name Time Method ot provided at time of registration