Comparison of Diclofenacsodium and Paracetamol for Acute postcraniotomy pain in patients undergoing supratentorial tumour surgery
Phase 4
Completed
- Conditions
- Health Condition 1: C719- Malignant neoplasm of brain, unspecified
- Registration Number
- CTRI/2019/04/018690
- Lead Sponsor
- PGIMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 110
Inclusion Criteria
Patients scheduled to undergo elective craniotomy for supratentorial tumours; ASA 1&2 patients; age 18-65 years of age
Exclusion Criteria
Pregnant/nursing women, BMI >35kg/m2; patients with difficult airway, H/O CHF, liver & kidney diseases, COPD, patients with poor GCS & severely raised ICP, Patient refusal, patients requiring >24hours postoperative mechanical ventilation and unable to communicate postoperatively
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare analgesic efficacy of diclofenacsodium sodium and paracetamol within first 48hours after supratentorial craniotomyTimepoint: To compare analgesic efficacy of diclofenacsodium sodium and paracetamol within first 48hours after supratentorial craniotomy
- Secondary Outcome Measures
Name Time Method Effect of paracetamol and diclofenacsodium on 1) need for rescue analgesia; 2) coagulation profile and platelet function,3) incidence of hem atoms formation/expansion, 4) incidence of PONV, 5)duration of postoperative hospital stay, 6) effect on LFT&RFTTimepoint: Assesed at 12hours 24 hours and at 48hours postoperatively <br/ ><br>