Effectiveness of Diclofenac versus Paracetamol in primary care patients with knee osteoarthritis.

Completed

• Conditions: Aandoeningen van het bewegingsapparaat; Knee osteoarthritis

• Registration Number: NL-OMON33703
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 154

Inclusion Criteria

- Complying to the clinical American College of Rheumatology (ACR) criteria for osteoarthrosis of the knee.
- Have an indication for pain medication.
- A score of 3 or more on the pain severity scale (0-10 scale).
- Patients* aged 45 years or older.

Exclusion Criteria

- Contra-indication for NSAID or Paracetamol use
- An arthroplasty or osteotomy of the knee in contralateral or unilateral side.
- Already taking NSAID or paracetamol medication of similar or higher doses as in the study.
- Surgery or major trauma of the affected joint within the previous 6 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcomes are pain and function measured with the Western Ontario<br /><br>and McMaster (WOMAC) Osteoarthritis Index calculated with the Knee<br /><br>Osteoarthritis Outcome Score (KOOS) over a maximum follow-up period of 12<br /><br>weeks. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes are: 1) patients* perceived pain, 2) Perceive recovery, 3)<br /><br>patients* quality of life, 4) all direct and indirect medical and patients*<br /><br>costs, 5) compliance to therapy, 6) co-interventions, and 7) adverse reactions.</p><br>