Effectiveness of Apneic Oxygenation for Morbid Obese Parturient Performing Elective Caesarean Section Under General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- the lowest oxygen saturation recorded
研究概览
简要总结
The aim of this study is to compare the effect of apneic preoxygenation to conventional preoxygenation on the oxygen desaturation in morbid obese parturient performing elective caesarean section under general anesthesia.
详细描述
Anesthetic management of the obese parturient is challenging. Both pregnancy and obesity are risk factors for a difficult airway and anesthesia-related maternal mortality. There is increased risk of difficult intubation associated with an increased difficultly in mask ventilation and increased risk of accelerated desaturation during apnea.
The use of apneic oxygenation for the optimization of peri-intubation conditions is a promising means of preventing hypoxemia.
Despite the recommendation of the use of nasal prongs to insufflate oxygen at flows of 5 L/min to 15 L/min during the apneic period randomized controlled trial is still not available in the morbidly obese parturient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Morbid obesity parturient defined as a body mass index (BMI) above 40 kg/m
- •ASA physical status I-II
- •Age above 18 years.
- •Scheduled for elective caesarean section under general anesthesia.
排除标准
- •Parturient of ASA physical status III or above.
- •Suspected or known difficult airway (Mallampati class > 2, reduced neck movement, reduced mouth opening, or Cormack-Lehane grade 4 recorded during a previous intubation procedure).
- •Any contraindication for nasal prong use, for example, tumours, fractures or trauma.
- •SpO2 ≤ 97% prior to preoxygenation.
结局指标
主要结局
the lowest oxygen saturation recorded
时间窗: during intubation procedure
percentage
次要结局
- rates of desaturation below SpO2 90%(during intubation procedure)
- rates of critical desaturation below SpO2 80%(during intubation procedure)
研究者
Wael Elswefi
lecturer
Ain Shams University