Allergy to Almond in Children

• Conditions: Food Allergy in Children

• Registration Number: NCT04407104
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Allergy to tree nuts are frequent in children but allergy to almond is one of the less described tree nuts allergy. The main objective of our study is to determine diagnostic values of skin prick-tests and specific IgE to almond in a population of children sensitized to almond and challenged in our unit from november 2013 to march 2020.

Detailed Description

Secondary objectives are

* description of allergic reactions to almond (symptoms, severity)

* modelisation of eliciting dose to almond in our population

* evaluation of the association between atopic comorbidities and allergy to almond in children sensitized to almond

* evaluation of the association between allergy to almond and the importance of skin and sIgE sensitization

Study Timeline

• Status Verified: 2020-05
• Study First Submitted: 2020-05-25
• Study First Submitted QC: 2020-05-25
• Study First Posted: 2020-05-29
• Study Start: 2020-07-20
• Last Update Submitted: 2020-07-20
• Last Update Posted: 2020-07-21
• Primary Completion: 2020-08-31
• Study Completion: 2020-09-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• oral food challenge to almond performed in the pediatric allergy department of the University Hospital of Nancy from november 2013 and march 2020

Exclusion Criteria

• doubtful or incomplete oral food challenge to almond

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diagnostic values of skin prick-test and sIgE to almond	BASELINE

Secondary Outcome Measures

Name	Time	Method
allergic reactions during oral food challenge	BASELINE	symptoms and severity
eliciting doses to almond	BASELINE	ED05, ED10 and ED50
atopic comorbidities	BASELINE	respiratory allergies, other food allergies, asthma