Artificial ventilation setting in patients infected with COVID-19

Not Applicable

Recruiting

• Conditions: Respiratory tract diseases; Virus diseases; Respiratory Distress Syndrome, Adult; C08.381.840

• Registration Number: RBR-2z3f7k
• Lead Sponsor: Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-05-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Age 18 to 80 years; Mechanically ventilated patients with COVID-19 infection suspicious

Exclusion Criteria

Pregnancy confirmed by laboratory tests;
• Weight below 35 kg; Patients undergoing endotracheal intubation as a result of exacerbation of chronic lung disease; Radiological aspects compatible with pulmonary fibrosis, consolidation of the lung parenchyma, tumor masses and emphysema; Patients with pneumatocele; Pneumothorax, subcutaneous emphysema and pneumomediastinum documented and not resolved; Patients with heart failure previously classified as functional class III or IV according to the New York Heart Association (NYHA); Patients with acute coronary syndrome or persistent ventricular tachyarrhythmias; Mean arterial pressure (MAP) less than 65 mmHg with a dose of norepinephrine 0.5 to 1.0 mg / kg / min; Acute brain injury or high intracranial pressure, that is, greater than 18 mmHg;

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of mechanical parameters between table adjustment and decremental titration<br>

Secondary Outcome Measures

Name	Time	Method
To evaluate the effects of individualized PEEP adjustment on gas exchange in patients with ARDS infected with COVID-19.<br><br>;Time of mechanical ventilation;Incidence of pneumothorax;Intrahospital mortality