Evaluation of Topical Chamomile Versus Topical Triamcinolone Acetonide in Management of Oral Lichen Planus

Phase 1

• Conditions: Oral Lichen Planus
• Interventions: Drug: topical chamomile

• Registration Number: NCT03793634
• Lead Sponsor: Cairo University

Brief Summary

Using of herbal medications as topical chamomile which has antioxidant, anti-inflammatory and anticarcinogenesis effect with little side effects is the aim for the future treatment of OLP.

Detailed Description

Oral lichen planus (OLP) is a chronic inflammatory T cell mediated autoimmune disease that affects skin and any mucous membrane particularly oral mucosa.The patient complains of burning sensation, pain; interference with eating, swallowing and speech leading to worsening of quality of life.Oxidative stress plays a role in pathomechanism of OLP disease. Enzymatic and non- enzymatic anti-oxidants act as a physiological guard against reactive oxygen species (ROS) and cytokine-mediated toxicity.Herbal treatment is the aim of the future therapy.Chamomile has anti-oxidant , anti-inflammatory effect and accelerate healing.

Study Timeline

• Status Verified: 2019-01
• Study First Submitted: 2019-01-03
• Study First Submitted QC: 2019-01-03
• Last Update Submitted: 2019-01-03
• Study First Posted: 2019-01-04
• Last Update Posted: 2019-01-04
• Study Start: 2019-01-15
• Primary Completion: 2019-12-01
• Study Completion: 2020-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Symptomatic OLP.
• Patients with no history of taking corticosteroids for the last 6 months.
• Patients who agree to take medication.
• Medically free

Exclusion Criteria

• Patients with oral lesions other than OLP.
• Lichenoid reaction .
• Pregnant females and lactation.
• Smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
topical chamomile	topical chamomile	herbal medication which has antioxidant, anti-inflammatory and anticarcinogenesis effect.
Topical Triamcinolone Acetonide	topical chamomile	topical triamcinolone acetonide is the gold standard treatment of oral lichen planus.

Primary Outcome Measures

Name	Time	Method
Pain using Numerical rating scale	1 month	Pain measure using Numerical rating scale

Secondary Outcome Measures

Name	Time	Method
clinical sign score	1 month	Reduction in clinical sign score using Thongprasom et al