Can objective measures of phenotypes of Insomnia Disorder built on either polysomnographic sleep or dim light melatonin onset predict treatment response (insomnia severity index scores, sleep onset latency & wake-time after sleep onset) to cognitive behavioural therapy compared to classic insomnia clinical phenotypes?

Woolcock Institute of Medical Research0 个研究点目标入组 325 人开始时间: 2015年7月21日最近更新: 2020年1月13日

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•1. Symptoms of Insomnia Disorder as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for insomnia disorder (APA, 2013) specifically: Difficulty initiating or maintaining sleep or waking up too early for at least 3 nights per week, for at least 3 months, with adequate opportunity and circumstances for sleep and at least one daytime impairment related to the sleep difficulty.
•2. Insomnia Severity Index score more than or equal to 10
•3. Fluent speaker of English
•4. Aged >18 years
•5. Stable sleep/wake schedule (habitual bedtime 22:00-00:00 +/- 2 hours)
•6. Able to give informed, written consent

•1. Pregnancy or lactation
•2. Active illicit substance use or alcohol/caffeine dependence
•3. Medications that interfere with sleep (within 1 month of assessment)
•4. Psychiatric disorders, other than mild to moderate depression (on the
•Depression Anxiety Stress Scales)
•5. Another sleep disorder evaluated by a Sleep Physician / Sleep Psychologist that better explains the complaint of sleep loss.
•6. Severe cognitive impairment that does not allow patients to consent or follow study instructions
•7. Overnight shift workers and recent time-zone travel (within last 2 months)
•8. Actively treated sleep disorder (e.g. CPAP/CBT-I)

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