跳至主要内容
临床试验/NCT04715880
NCT04715880已完成不适用

The Comparison of the Analgesic Efficacy and Hemodynamic Effects of Paravertebral Block Compared With Paravertebral and Intercostal Nerve Block for Thoracotomy in Adults: A Randomized Controlled Trail

Aga Khan University Hospital, Pakistan1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2021年2月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
70
试验地点
1
主要终点
Blood Pressure

研究概览

简要总结

Thoracotomy is a surgical procedure associated with severe post operative pain during the first day of surgery and is responsible for prolonged hospital stay, patient dissatisfaction and delayed return to normal activities along with increased morbidity and mortality. Investigators intend to compare the efficacy of two analgesic interventions (continuous infusion of paravertebral block (PVB) after loading dose compared with intercostal nerve block and continuous infusion of PVB without loading dose) on postoperative thoracotomy pain. The results of this study will direct the investigators to find the best practice methods which will reduce the postoperative thoracotomy pain, the overall cost of pain management and length of patient's hospital stay.

详细描述

Objective To compare the safety, efficacy for pain relief and hemodynamic changes of two analgesic interventions(continuous infusion of Paravertebral block (PVB) after loading dose compared with intercostal nerve block and continuous infusion of PVB without loading dose)

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All ASA I-IV adult patients between the ages of 18-70 years scheduled for elective thoracotomy
  • Either sex

排除标准

  • Neurological or psychiatric diseases
  • Emergency Procedures.
  • Language barrier
  • Patients under chronic treatment with opioids
  • Patients with hypersensitivity to bupivacaine
  • Coagulation disorders.
  • Unwilling to participate.
  • Patient previously involved in other studies

结局指标

主要结局

Blood Pressure

时间窗: 24 hours

Blood pressure in mmHg

Pain Score

时间窗: 24 hours

Visual Analogue Scale (VAS) pain Score in cm (0cm = No pain and 10 cm= Worst pain possible)

Heart Rate

时间窗: 24 Hours

Heart rate per minute

次要结局

  • Sedation score(24 hours)
  • Total postoperative narcotic consumption(24 hours)

研究者

发起方
Aga Khan University Hospital, Pakistan
申办方类型
Other
责任方
Principal Investigator
主要研究者

Kumar Sundeep

Trainee Medical Officer Anaesthesiology

Aga Khan University Hospital, Pakistan

研究点 (1)

Loading locations...

相似试验