Does manual lymphatic drainage decrease intracerebral pressure? – A pilot study

Not Applicable

• Conditions: TBI, SAH, ICH, brain tumor, stroke; S06; I63; C71; I61; Intracranial injury; Cerebral infarction; Malignant neoplasm of brain; Intracerebral haemorrhage

• Registration Number: DRKS00007648
• Lead Sponsor: Klinikum Kassel, Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-05
• Study Completion: 2015-07-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

o acute cerebral disease,

o treatment on the Neuro-intensive care unit, Klinikum Kassel,

o patient`s with intracranial cerebral monitoring (Neurovent-P, Raumedic AG, Münchberg, Germany),

o Intracranial pressure (before therapy) < 20mmHg,

o patient consent form,
>= 18 years

Exclusion Criteria

Common exclusion criteria`s for manual lymphatic drainage
o congestive heart failure,
o acute inflammation (generalized (sepsis) or localized in the head-neck area,
o malignant tumor,
Furthermore there are those exclusion criteria`s:
o missing patient consent,
o patient`s age < 18 years,
o hemodynamic instability: Kriterium: shock index < 1 within the last 6 hours,
o acute pulonary insufficency: Horowitz Index < 200,
o Intracranial pressure (before) = 20mmHg,
o elevated intracranial pressure > 30mmHg within the last 6 hours,
o temperature > 38,5°C within the last 6 hours,
o glucose level < 60mg/dl or > 500 mg/dl within the last 6 hours,
o PH < 7,35 or > 7,45 within the last 6 hours,
o ICP-therapy within the last 6 hours (defined as: Elevation of analgosedation, Osmo-therapy, hypertonic NaCl, ventricular drainage, neurosurgery, TRIS buffer)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
intracranial pressure (ICP) and cerebral perfusion pressure (CPP), measurements with a device, every minute for 15 minutes before treatment, during manual lymphatic drainage (duration 30 minutes), for 15 minutes after treatment (follow-up period)

Secondary Outcome Measures

Name	Time	Method
heart frequency, mean arterial blood pressure Measurements every minute for 15 minutes before treatment, during manual lymphatic drainage (duration 30 minutes), for 15 minutes after treatment (follow-up period)