Palliative use of nasal high-flow oxygen compared with standard therapy in do-not-intubate patients: A randomized crossover study
Not Applicable
Completed
- Conditions
- Dypsnea in do-not-intubate patientDypsneado-DNIpalliativeshortness of breathhigh flow oxygen cannulaconventional oxygen therapy
- Registration Number
- TCTR20171107001
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
1.Age > 18 years old
2.Do-not-intubate status
3.Presented with respiratory distress meeting all of the following criteria
a.Pulse oximetry < 90% when breathing at room air
b.Dyspnea (modified Borg scale ≥ 4)
c.Signs of respiratory distress e.g. accessory muscle use
d.Respiratory rate ≥ 30 breaths/min
4.Competent status: Kelly score < 4
Exclusion Criteria
1.Refusal of treatment
2.Agitation or non-cooperation
3.Adverse reactions or contraindication to opioids
4.Participants contraindicated for NHF such as excessive secretion, risk of aspiration
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in degree of dypsnea 15th, 30th, 60th, 75th, 90th, 120th minute Modified Borg scale
- Secondary Outcome Measures
Name Time Method Degree of dyspnea 15th, 30th, 60th, 75th, 90th, 120th minute Numeric rating scale,Total morphine use in 1-hour and 2- hour period milligram,Respiratory rate 15th, 30th, 60th, 75th, 90th, 120th minute Direct auscultation of respiratory cycle,SpO2 15th, 30th, 60th, 75th, 90th, 120th minute pulse oximetry,Heart rate and blood pressure 15th, 30th, 60th, 75th, 90th, 120th minute automatic blood pressure and heart rate monitor,Adverse event rate from equipment use within 2 hour of intervention Patient reported by themself,Hospital length of stay Until hospital discharge Hours, days,Mortality rate Until hospital discharge Discharge status