Comparative evaluation of Enamel matrix derivative (Emdogain) with demineralised freeze dried bone allograft (DFDBA) for the treatment of Intrabony defects - A Randomised Controlled Trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- -Radiographic Bone Fill (RBF %)
研究概览
简要总结
Periodontal regeneration is the restoration of the lost periodontium or supporting tissues which includes formation of new alveolar bone, new cementum and new periodontal ligament. Enamel Matrix Derivative(EMD) is a biological agent capable of periodontal regeneration. it has been demonstrated that EMD exerts a significant influence on cell behaviour of many cell types by mediating cell attachment, spreading, proliferation, differentiation. It plays a significant role in changing OPG/RANKL balance by increasing OPG and decreasing RANKL levels resulting in diminished osteoclast formation and activity. DFDBA is a bone graft material assumed to induce bone formation due to the influence of bone inductive proteins called BMPs which help in osteogenesis and bone formation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 35.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Contained defects were included.
- •A full-mouth plaque score ≤ 20% at the time of the surgical procedure.
- •Probing depth (PD) ≥ 6 mm and an associated intrabony defect with a depth of ≥ 3 mm as measured on the periapical radiograph.
排除标准
- •Systemic diseases contraindicating periodontal surgery
- •Medications affecting periodontal status
- •Pregnancy or lactation
- •Smoking habits
- •Third molars and teeth with inadequate endodontic treatment.
结局指标
主要结局
-Radiographic Bone Fill (RBF %)
时间窗: Baseline and 3 months post operatively
-Clinical Attachment Level gain
时间窗: Baseline and 3 months post operatively
次要结局
- -Plaque score(-Periodontal Pocket Depth (PPD))
研究者
Dr Renuka Metgud
Department of Periodontics, Room No. 9, KAHER KLE VK Institute of Dental Sciences