Cognitive Behavioural Therapy for Children With Autism Spectrum Disorder and Obsessive Compulsive Behaviour

Not Applicable

Completed

• Conditions: Obsessive-Compulsive Behavior; Autism Spectrum Disorder
• Interventions: Behavioral: Functional Behavior-Based Cognitive Behavioral Therapy

• Registration Number: NCT03123146
• Lead Sponsor: Tricia Vause

Brief Summary

Individuals with high functioning autism spectrum disorder (ASD) frequently experience obsessions and/or compulsions that are similar to those specified in Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for obsessive compulsive disorder (OCD). However, little research exists on effective interventions for OCD symptoms (referred to as OCBs) in ASD. In a randomized controlled trial, a manualized functional behavior-based cognitive-behavior therapy (Fb-CBT) consisting of traditional CBT components (psychoeducation and mapping, cognitive-behavioral skills training, exposure, and response prevention) as well as function-based behavioral assessment will be evaluated. Participants will be assigned randomly to Fb-CBT or treatment as usual (TAU). Primary and secondary outcome measures will be used to evaluate the efficacy of the treatment, and will be administered at pre and post-intervention as well as six month follow-up.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-06-01
• Primary Completion: 2014-02-01
• Study Completion: 2014-02-01
• Status Verified: 2017-04
• Study First Submitted: 2017-04-13
• Study First Submitted QC: 2017-04-19
• Last Update Submitted: 2017-04-19
• Study First Posted: 2017-04-21
• Last Update Posted: 2017-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• Previous diagnosis of ASD
• Presence of OCBs as defined by Sameness, Ritualistic and Compulsive subscales on the RBS-R
• a Full Scale IQ (WISC-IV; Wechsler, 2004) ≥ 70
• parent indicated no planned change in child medication during the study (unless the physician deemed the change medically necessary)

Exclusion Criteria

• participation in treatment for anxiety
• participation in treatment for repetitive behaviour
• participation in treatment for intensive behavioural intervention

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Fb-Cognitive Behavioral Therapy	Functional Behavior-Based Cognitive Behavioral Therapy	Functional Behavior-Based Cognitive Behavioral Therapy: Group activities, individual work in parent-child dyads, group parent training, and social skills exercises.

Primary Outcome Measures

Name	Time	Method
Change in Repetitive Behavior Scale (RBS_SCR)	Assessment occurred at baseline and 2 weeks following end of treatment, as well as at follow-up (6 months following the cessation of treatment)	The RBS is a 43-item parent rating measure of repetitive behavior. It is comprised of a four-point Likert scale ranging from (0) behavior does not occur, to (3) behavior occurs and is a severe problem . The RBS_SCR scale specifically focusses on the assessment of sameness, compulsive, and ritualistic behaviors
Change in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS)	Assessment occurred at baseline and 2 weeks following end of treatment	A 10-item, semi-structured interview used to assess symptom severity for children ages 6 through 17 years. Each item is rated on a 5-point ordinal scale from 0 (none) to 4 (extreme)' For the purpose of this study, only the 5-item Compulsion score was used pre and post-treatment.

Secondary Outcome Measures

Name	Time	Method
Change in The child Obsessive-Compulsive Impact Scale-Revised (COIS-R)	Assessment occurred at baseline and 2-weeks following the end of treatment, as well as at follow-up (6 months following the cessation of treatment)	A 33-item, parent-report questionnaire that assesses OCD-related impairment in various areas of the child's life, including school, social, and home/family activities. For each item, the parent rates the child's level of impairment on a 4-point Likert scale from 0 (not at all) to 3 (very much).
Parent OCB Rating Scale.	Scale was completed by parents at baseline, each day throughout the 9-week treatment period, and at follow-up (6 months following the cessation of treatment)	A Likert-type scale ranging from 1 (desired post-treatment levels of OCBs) to 3 (partial improvement from pre-treatment levels) to 5 (pre-treatment levels of OCBs) was used by parents to rate OCBs.
Change in Repetitive Behavior Scale 100 (RBS_100)	Assessment occurred at baseline and 2 weeks following the end of treatment, as well as at follow-up (6 months following the cessation of treatment)	The final item on the RBS-R asks caregivers to rate on a scale from 1 to 100 how much OCBs affect the child and the people around them (1 is not a problem to 100 is as bad as can be imagined; Bodfish et al., 1999).

Trial Locations

Locations (1)

Brock University; 🇨🇦 St Catharines, Ontario, Canada