Compulsive patterns of behaviour in Autism Spectrum Disorder and Obsessive Compulsive Disorder
Completed
- Conditions
- autism spectrum disorder and obsessive compulsive disorder10012562
- Registration Number
- NL-OMON39641
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
(1) Aged 8-12 years
(2) For Autism Spectrum Disorder: DSM-IV-TR diagnosis of ASD
(3) For Obsessive Compulsive Disorder: DSM-IV-TR diagnosis of OCD
(4) For Controls: no psychiatric diagnosis and no history of psychiatric illness in first or second-degree familiy members.
(5) Signed informed consent
Exclusion Criteria
(1) Mental retardation (IQ<70)
(2) Major physical illness of the cardiovascular, endocrine, pulmonal or gastrointestinal system
(3) All contra indications for MRI assessment (pacemaker, dental braces)
(4) History of or present neurological disorder
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary endpoints are phenotypic meassures of compulsivity, impulsivity and<br /><br>addiction, and functional and connectivity measures (fMRI, DTI-MR) of striatal<br /><br>and prefrontal regions.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary endpoints are (1) genotypes of candidate genes and (2) lab assesments<br /><br>of various proteins in blood plasma.</p><br>