A Randomized Controlled Trial to Compare the Effect of Intra -Articular Adalimumab Versus Intra - Articular Hyaluronic Acid in Primary Osteoarthritis of the Knee

All India Institute of Medical Sciences0 sites0 target enrollmentTBD

ConditionsHealth Condition 1: null- Primary Osteoarthritis of the Knee

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Health Condition 1: null- Primary Osteoarthritis of the Knee
Sponsor: All India Institute of Medical Sciences
Status: Recruiting
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Investigators

Sponsor

All India Institute of Medical Sciences

Eligibility Criteria

Inclusion Criteria

•1\. Diagnosis of Knee OA as per 2016 ACR Revised Criteria for Early Diagnosis of Knee OA
•2\. Unilateral Primary OA of Grade 2 or Grade 3 on Kellgren Lawrence Scale
•3\. Pain Score \>4 on VAS( Visual Analogue Scale) within the past one month
•4\. Lack of efficacy of previous treatment with Diclofenac at a dose of 75mg/day

Exclusion Criteria

•1\. Previous treatment with TNF inhibitors
•2\. Previous Intra \- Articular treatment within 3 months
•3\.Previous Knee Surgery
•4\. History of tumor or serious Infection
•5\. Pregnancy
•6\. Lactation
•7\. Cognitive Impairment
•8\. Previous history of trauma to the knee

Outcomes

Primary Outcomes

Not specified

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