Comparing Metabolic and Nutrition Characteristics of Persistent Critically Ill Non-COVID and COVID-19 Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Energy balance
研究概览
简要总结
The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI). Little is known about their metabolic and nutritional characteristics compared to other non-COVID (non-CO) categories of patients.
The aim is to compare the metabolic characteristics and gastro-intestinal function of the previously admitted non-CO and COVID persistent critically ill patients, and the adherence to the ICU nutrition protocol.
Prospective observation study including two consecutive cohorts of PCI, defined by a prolonged mechanical ventilation requirement longer than 10days.
详细描述
The metabolic and nutritional characteristics of the COVID-19 patients requiring prolonged ICU treatment compared to other non-COVID (non-CO) categories of patients remain poorly described. The aim was to compare the metabolic characteristics of the previously admitted non-CO and COVID PCI patients.
Prospective observation study including two consecutive cohorts of PCI, defined as requiring a mechanical ventilation for >10 days.
The comparative cohort is the first patient cohort previously registered as NCT03938961.
Variables: demographic data, severity score (SAPS2, organ failure (SOFA) scores), Nutrition Risk Screening (NRS) score, C-reactive protein (CRP), blood phosphate. Nutritional variables: energy intake (detail of protein, lipids, glucose), fasting time, feeding route, prealbumin values, bowel activity, insulin requirements Outcome: length of mechanical ventilation, ICU and hospital stay and outcome. Descriptive statistics
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients requiring more than 10 days on mechanical ventilation
排除标准
- •patients refusing use of their coded data
- •admission for brain injury or after cardiac arrest
- •admission for major burns >20% body surface area (BSA)
结局指标
主要结局
Energy balance
时间窗: up to 30 days
Delta between energy delivery and prescription
次要结局
- Feeding route and time to feeding(up to 30 days)
- Hypophosphataemia(up to 30 days)
- Insulin resistance(up to 30 days)
- Bowel activity(up to 30 days)
- Length of ICU and hospital stay(up to 3 months)
研究者
Mette M Berger
Professor Emeritus, Research Staf, Adult Intensive Care Department
Centre Hospitalier Universitaire Vaudois