Understanding the Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Tissue factor expression in tumors
研究概览
简要总结
The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition. The main question it aims to answer is:
Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time?
Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagina before, during, and on the last day of radiation therapy.
详细描述
The standard of care treatment for locally advanced cervical cancer is a combination of chemotherapy with cisplatin and radiotherapy. Although patients have improved outcomes with chemo-radiotherapy, tumor recurrence can occur. In addition, combining chemotherapy with radiotherapy increases treatment-related side effects. While breakthroughs in radiotherapy and immunotherapy have resulted in targeted cancer care, chemotherapy given with radiotherapy is a non-targeted approach. Better strategies to treat cervical cancer are needed.
In this study, the investigators will use tissue and blood from patients with cervical cancer to perform translational research. This is necessary to discover molecular pathways that could be targeted in the future with novel agents, such as radiotherapy and immunotherapy, for the treatment of women with cervical cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Pathological diagnosis of cervical cancer
- •Scheduled to receive brachytherapy for cervical cancer
排除标准
- •Pregnancy or lactation
- •Inability to provide a tissue sample
结局指标
主要结局
Tissue factor expression in tumors
时间窗: 8 weeks
Determine the temporal changes of tissue factor expression in the irradiated tumor immune microenvironment.
次要结局
未报告次要终点
研究者
Jyoti Mayadev, MD
Professor, Radiation Medicine and Applied Sciences
University of California, San Diego