Expression of cytokeratins and notch in the healthy folliculopilosebaceous unit

Completed

• Conditions: acne ectopica; acne inversa; 10040798

• Registration Number: NL-OMON42336
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- Subjects are not affected with HS
- Subjects do not have another skin disease located at the armpits or groins
- Age 18-50 years

Exclusion Criteria

- Subjects who have not given informed consent
- Subjects with a skin disease located in the armpits and groins

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The intensity of the stainings will be measured at the 6 segments of the FPSU:<br /><br>bulb, bulge,<br /><br>isthmus, sebofollicular junction, infundibulum and interfollicular epidermis.<br /><br>For each skin sample<br /><br>the intensity of all performed IF stainings at the aforementioned individual<br /><br>segments will be<br /><br>analyzed using Image J software.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The intensity of the stainings will be measured at the 6 segments of the FPSU:<br /><br>bulb, bulge,<br /><br>isthmus, sebofollicular junction, infundibulum and interfollicular epidermis.<br /><br>For each skin sample<br /><br>the intensity of all performed IF stainings at the aforementioned individual<br /><br>segments will be<br /><br>analyzed using Image J software. Next, the association between expression of<br /><br>the cytokeratins and Notch 1 will be examined. Notch 1 expression will be the<br /><br>independent variable, the expression of the different cytokeratins the<br /><br>dependent variable. </p><br>