Comparison of antioxidant and inflammatory cytokine activities in tears of patients with dry eye syndrome treated with preservative-free vs preserved eye drops

Bucheon St. Mary's Hospital (Korea, South)0 个研究点目标入组 100 人开始时间: 2014年2月5日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•Eligible patients were at least 21 years of age and had a diagnosis of dry eye syndrome refractory to conventional management. Inclusion criteria were:
•1. Schirmer test (without anesthesia) of 5 mm/5 minutes in at least one eye
•2. Low tear film break-up time (tBUT) (<5 seconds)
•3. Mild superficial punctate keratitis, defined as a corneal punctate fluorescein staining score of =1 in either eye (scale 0 [none] to 3 [severe]); and one or more moderate (=2) dry eye related symptoms, including itching, burning, blurred vision, foreign body sensation, dryness, photophobia, soreness, or pain.

•Patients were excluded if they had:
•1. A history of any ocular disorder including injury, infection, non-dry-eye ocular inflammation, trauma, or surgery within the prior 6 months
•2. Were receiving concurrent treatment that could interfere with interpretation of the study results
•3. Had any uncontrolled systemic disease or significant illness; or were pregnant, lactating, or considering becoming pregnant.
•4. Patients could be discontinued before the completion of the study because of adverse events, pregnancy, protocol violations, lack of efficacy, or administrative or personal reasons.

发起方

Bucheon St. Mary's Hospital (Korea, South)