Comparative trials of clinical course of low-dose rosuvastatin and ezetimibe combination therapy and high-dose rosuvastatin monotherapy in patients with minimal to intermediate coronary artery disease

Not Applicable

Recruiting

Conditions: Diseases of the circulatory system

Registration Number: KCT0009035

Lead Sponsor: The Catholic University of Korea, St. Vincent's Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 6356

Inclusion Criteria

1)Male and female adjusts (19 or older)
2)Patients with suspected stable angina pectoris without coronary artery interventions, who showed a minimal to intermediate coronary artery disease (a stenosis of 10 to 70% diameter as per QCA) in at least one natural coronary artery in coronary artery angiography or coronary artery CT.
3)Patients who gave their informed consent themselves in writing.
4)Patients who were treated with statin or lipid-lowering agents may participate in the study by changing the existing medicines.

Exclusion Criteria

1)Patients with an intermediate (>30%) lesion on the left main coronary artery.
2)Patients diagnosed with acute coronary artery syndrome (STEMI, NSTEMI, Unstable angina)
3)Patients who received percutaneous coronary intervention
4)Patients who have been diagnosed with stroke, transitory ischemic attack, and peripheral artery diseases.
5)Patients diagnosed with variant angina
6)Patients with severe liver diseases or lung diseases and/or malignant tumor
7)Patients with severe valvular heart disease
8)Patients who are hypersensitive or prohibited from using the active substance (Ezetimibe or Rosuvastatin) of the study medicines
9)Patients whose remaining life expectancy is less than a year
10)Patients with cardiogenic shock
11)Pregnant women or women who are planning to get pregnant
12)Patients who are receiving hemodialysis or peritoneal dialysis or received renal transplantation due to end-stage renal failure
13)Patients who participated in other clinical studies within the past three months (except for non-interventional observation studies)

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
all cause deaths, cardiac deaths, non-fatal myocardial infarction, non-fatal stroke, hospitalization due to unstable angina, and revascularization after randomization

Secondary Outcome Measures