Multimodal Analgesia for the Reduction of Postoperative Opioid Consumption
Overview
- Phase
- Early Phase 1
- Intervention
- Multimodal analgesia
- Conditions
- Pain
- Sponsor
- Massachusetts General Hospital
- Primary Endpoint
- Change in post-operative opioid consumption
- Status
- Withdrawn
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators are performing this research study to investigate the efficacy of local infiltration of the surgical wound combining dexmedetomidine, ropivacaine, and ketorolac (treatment group) versus the current standard of care (historical control group), for post-operative pain management.
Detailed Description
During this research study, patients recommended for a rectus sheath block during surgery will receive a novel combination of non-opioid drugs. Data from the treatment group will be compared to surgical outcomes of a historically matched control group to investigate the ability of this drug combination to reduce post-operative pain and post-operative opioid consumption.
Investigators
Emery Brown
Director, Neuroscience Statistics Research Laboratory
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Age greater than 18 years
- •American Society of Anesthesiologist Physical Status Classification 1-3
- •Undergoing surgery requiring a rectus sheath block
Exclusion Criteria
- •American Society of Anesthesiologist Physical Status Classification of 4 or beyond
- •history of opiate of illicit substance abuse, chronic pain, or neurological dysfunction
Arms & Interventions
Multimodal Analgesia
Intervention: Multimodal analgesia
Outcomes
Primary Outcomes
Change in post-operative opioid consumption
Time Frame: 48 hours
Decreased post-operative opioid consumption associated with use of multimodal analgesia
Change in post-operative pain scores
Time Frame: 48 hours
Decreased post-operative pain scores associated with use of multimodal analgesia