Variability in muscular adaptation to strength training: Intra- and inter-individual differences in the adaptation reactions of the skeletal muscles to a maximum strength training load with increased eccentric load compared to the conventional maximum strength load

Phase 3

• Conditions: Strength training

• Registration Number: DRKS00027803
• Lead Sponsor: niversitätsklinikum Heidelberg, Medizinische Klinik, Innere Medizin VII: Sportmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-20
• Study Completion: 2023-07-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 26

Inclusion Criteria

healthy non-professional athletes; regular training (at least 3x/week), including strengh training 1-2x/week

Exclusion Criteria

Lack of understanding of language and thus lack of opportunity for enlightenment; missing written declaration of consent; diseases (abnormalities) of the musculoskeletal system such as arthrosis, spondylarthrosis, joint or spinal deformity; history of hypersensitivity to local anesthetics; cardiovascular disease (e.g. hypertension, coronary heart disease, hemodynamically relevant valve defects, high-grade cardiac arrhythmia); any acute or chronic illness (e.g. infectious diseases); disruption of coagulation activity; history of muscle disease; regular use of medication, especially non-steroidal anti-inflammatory drugs; use of creatine supplements

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In the planned project, it is to be investigated whether an intensive concentric/eccentric strength training load of the leg extensors with increased eccentric load (CON/ECC+) causes an increased activation, proliferation and differentiation of satellite cells than an intensive conventional concentric/eccentric strength training load (CON/ECC). In order to avoid the effects of inter-individual variability, the effects of both strength training methods on both legs of one and the same test subject are to be examined at the same times.

Secondary Outcome Measures

Name	Time	Method
Characteristics are to be identified that allow a prediction of the extent of the reactions to an exhausting training stimulus and the course of regeneration.