Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure

Lakehead University2 sites in 1 country28 target enrollmentStarted: December 4, 2023Last updated: September 24, 2026

Conditions

Interventions

Drugs

Trial Snapshot

Phase: Not Applicable
Status: Completed
Sponsor: Lakehead University
Enrollment: 28
Locations: 2
Primary Endpoint: Skin Temperature

Study Overview Study Design Eligibility Criteria Arms & Interventions Outcomes Investigators Sites Records & Identifiers Similar Trials

Study Overview

Brief Summary

Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1/5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https://doi.org/10.1186/s12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.

Therefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.

Study Design

Study Type: Interventional
Allocation: Randomized
Intervention Model: Crossover
Primary Purpose: Basic Science
Masking: Single (Participant)

Eligibility Criteria

Ages: 19 Years to — (Adult, Older Adult)
Sex: All
Accepts Healthy Volunteers: Yes

Inclusion Criteria

•Male or Female above the age of 19
•Able to provide informed consent

Exclusion Criteria

•History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence
•Been hospitalized due to COVID-19
•Pregnant/Breastfeeding
•Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)

Arms & Interventions

Alcohol

Active Comparator

Consumption of alcohol beverages: females 0.75 ± 0.1 grams of ethanol/kilogram body mass; males 1.0 ± 0.1 grams of ethanol/kilogram body mass

Intervention: Alcohol (Ethanol) (Drug)

Placebo

Placebo Comparator

Placebo (non-alcoholic beverage)

Intervention: Placebo Beverage (Drug)