Regional Citrate Anticoagulation for acute intermittent hemodialysis versus saline flushing for safety, efficacy and effect on prolong life of blood circuit of hemodialysis machine; Randomized controlled trial
Phase 3
Recruiting
- Conditions
- Hypocalcemia,lead to numbness,carpopedal spasm,seizure and arrhythmiaMetabolic alkalosis
- Registration Number
- TCTR20200630004
- Lead Sponsor
- Government
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 300
Inclusion Criteria
Patients were eligible for enrollment if they were aged 18Â years or older
Patients with AKI requiring RRT, acute intermittent hemodialysis
Contraindication to systemic anticoagulation or medium-to high bleeding risk during hemodialysis
Informed consent
Exclusion Criteria
Patients were treated with antiplatelet ,oral anticoagulant therapy or other drugs known to affect coagulation within 7 days
Acute liver failure or DIC
Abnormal plasma total calcium < 7.0 mg/dL
Documented arrhythmia
Known allergy to citrate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of dialyzer clotting 30, 60, 120,240 min after start regional citrate infusions Number of dialyzer clotting
- Secondary Outcome Measures
Name Time Method Circuit survival time Time to first event of dialyzer clotting minute