To compare the effects of fentanyl and dexmedetomidine in pain relief

Phase 1/2

Not yet recruiting

• Conditions: Fracture of shaft of humerus, (2) ICD-10 Condition: S520||Fracture of upper end of ulna,

• Registration Number: CTRI/2021/08/035547
• Lead Sponsor: JNMCH

Brief Summary

TITLE OF THESIS:A COMPARATIVE EVALUATION OF THE EFFECTS OF FENTANYL AND DEXMEDETOMIDINE AS AN ADJUANT TO BUPIVACAINE IN ULTRASOUND GUIDED SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK.

IINTRODUCTION: In general, regional nerve blockade avoids the unwanted effects of anaesthetic drugs used during general anaesthesia and is beneficial for the patients with various cardio-respiratory co-morbidities. Brachial plexus block is the most popular technique to deal with the upper limb surgeries.Various adjuants ,including opioids , midazolam, magnesium sulfate, dexamethasone, and neostigmine have been added to local anaesthetics in an attempt to increase the duration of block and post-operative analgesia.Various clinical trials have found that administration of dexmedetomidine and fentanyl with local anaesthetics in neuraxial and peripheral nerve blocks prolonged the duration of sensory and motor blockade. However, there are limited data available on comparison of dexmedetomidine and fentanyl as adjuant to local anaesthetics in brachial plexus block.

HYPOTHESIS:Dexmedetomidine is better than fentanyl in terms of duration of both motor and sensory blocks and postoperative analgesia.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-06-08
• Study Start: 2021-08-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1)ASA I&II Patients of either sex.
• 2)Age between 15-60 yrs.
• 3)Weight 40-80kg.
• 4)Patients planned for elective upper limb surgery.

Exclusion Criteria

• 1)Patients with cardiovascular diseases like coronary artery disease, hypertension ,heart blocks etc.
• 2)Patients with disease like diabetes ,peripheral neuropathy, coagulopathy.
• 3)Infection at the site of block .
• 4)Patients with known allergy to local anaesthetic and patients on adrenoceptor agonist or antagonists.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the effect of fentanyl and dexmedetomidine as an adjuant to	base line | immediately after injection | every 15 min till 2 hrs
bupivacaine on onset and duration of block and postoperative analgesia in	base line | immediately after injection | every 15 min till 2 hrs
ultrasound guided supraclavicular brachial plexus block.	base line | immediately after injection | every 15 min till 2 hrs

Secondary Outcome Measures

Name	Time	Method
1. To compare the haemodynamic changes –	a) Heart Rate(HR)

Trial Locations

Locations (1)

JAWAHAR LAL NEHRU MEDICAL COLLEGE; 🇮🇳 Aligarh, UTTAR PRADESH, India

JAWAHAR LAL NEHRU MEDICAL COLLEGE

🇮🇳Aligarh, UTTAR PRADESH, India

SHAMSE ALAM

Principal investigator

9634367980

shamsealam91@yahoo.com