NCT01782820已完成不适用
Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium
Kreiskrankenhaus Dormagen1 个研究点 分布在 1 个国家目标入组 108 人开始时间: 2011年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.
研究概览
简要总结
The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients aged 18 to 65 years,
- •American Society of Anesthesiologists Physical Status I or II,
- •50-90 kg body weight,
- •undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.
排除标准
- •expected difficulties with endotracheal intubation (history of difficult intubation,
- •reduced opening of the mouth (< 2cm), and Mallampati Score of 4),
- •increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction),
- •known allergies to the drugs tested,
- •pregnancy,
- •neuromuscular disorders,
- •intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins,
- •hepatic-or renal insufficiency.
结局指标
主要结局
the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.
时间窗: one hour
次要结局
未报告次要终点
研究者
研究点 (1)
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