Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium

Completed

• Conditions: Neuromuscular Block, Recovery; Neuromuscular Block, Dexamethasone

• Registration Number: NCT01782820
• Lead Sponsor: Kreiskrankenhaus Dormagen

Brief Summary

The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-12
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Study First Submitted: 2013-01-31
• Study First Submitted QC: 2013-02-01
• Study First Posted: 2013-02-04
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-16
• Last Update Posted: 2022-08-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 108

Inclusion Criteria

• patients aged 18 to 65 years,
• American Society of Anesthesiologists Physical Status I or II,
• 50-90 kg body weight,
• undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.

Exclusion Criteria

• expected difficulties with endotracheal intubation (history of difficult intubation,
• reduced opening of the mouth (< 2cm), and Mallampati Score of 4),
• increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction),
• known allergies to the drugs tested,
• pregnancy,
• neuromuscular disorders,
• intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins,
• hepatic-or renal insufficiency.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.	one hour

Trial Locations

Locations (1)

Kreiskrankenhaus Dormagen; 🇩🇪 Dormagen, Germany