Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium
Completed
- Conditions
- Neuromuscular Block, RecoveryNeuromuscular Block, Dexamethasone
- Registration Number
- NCT01782820
- Lead Sponsor
- Kreiskrankenhaus Dormagen
- Brief Summary
The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 108
Inclusion Criteria
- patients aged 18 to 65 years,
- American Society of Anesthesiologists Physical Status I or II,
- 50-90 kg body weight,
- undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade.
Exclusion Criteria
- expected difficulties with endotracheal intubation (history of difficult intubation,
- reduced opening of the mouth (< 2cm), and Mallampati Score of 4),
- increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction),
- known allergies to the drugs tested,
- pregnancy,
- neuromuscular disorders,
- intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins,
- hepatic-or renal insufficiency.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9. one hour
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kreiskrankenhaus Dormagen
🇩🇪Dormagen, Germany