Ultra-sound Guided Bilateral Quadratus Lumborum Block Versus Epidural Block for Postoperative Analgesia After Major Abdominal Surgeries.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Postoperative 24 hours cumulative rescue morphine consumption
研究概览
简要总结
Acute postoperative pain is an important issue after major abdominal surgeries for which different analgesic modalities have been tried.
Epidural analgesia is the recommended technique to relieve pain after major abdominal surgeries owing to the proved superior analgesia, reduction of opioid-related side effects as nausea, vomiting, pruritis and sedation, earlier recovery of bowel function and earlier ability for postoperative mobility. However, it is not without complications.
Quadratus lumborum block is an ultrasound-guided block that provides patients with both visceral and somatic blockade. It lessens the potential risks associated with neuraxial techniques, so it may represent a novel alternative approach for analgesia after major abdominal surgeries.
详细描述
The aim of this study is to detect the feasibility of ultra-sound guided bilateral quadratus lumborum block as a postoperative analgesic modality after major abdominal surgery in comparison to epidural block and its effects on total rescue analgesic requirements in the 1st postoperative 24hours, time to first analgesic request, pain VAS scores, intraoperative and postoperative hemodynamics and postoperative opioid-related side effects.
Under complete aseptic conditions, the patients will receive either thoracic epidural block or bilateral ultrasound-guided quadratus lumborum block after induction of general anaesthesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
Single blind study
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) physical status I-III
排除标准
- •Patient's refusal
- •Significant cardiac, disease.
- •Significant hepatic disease.
- •Significant renal disease (serum creatinine ˃ 1.5 mg/dl).
- •Patients with drug abuse
- •Allergy to study medications
- •Mental disease
- •Communication barrier.
- •Coagulopathy.
- •Local skin infection
研究组 & 干预措施
Thoracic epidural block
Patients will receive thoracic epidural block following induction of general anaesthesia
干预措施: Thoracic epidural block (Other)
Thoracic epidural block
Patients will receive thoracic epidural block following induction of general anaesthesia
干预措施: Induction of general anaesthesia with propofol (Drug)
Thoracic epidural block
Patients will receive thoracic epidural block following induction of general anaesthesia
干预措施: Muscle Relaxant (Drug)
Thoracic epidural block
Patients will receive thoracic epidural block following induction of general anaesthesia
干预措施: Maintenance of general anaesthesia (Drug)
Bilateral quadratus lumborum block
Patients will receive Ultrasound-guided bilateral quadratus lumborum block following induction of general anaesthesia
干预措施: Ultrasound-guided bilateral quadratus lumborum block (Other)
Bilateral quadratus lumborum block
Patients will receive Ultrasound-guided bilateral quadratus lumborum block following induction of general anaesthesia
干预措施: Induction of general anaesthesia with propofol (Drug)
Bilateral quadratus lumborum block
Patients will receive Ultrasound-guided bilateral quadratus lumborum block following induction of general anaesthesia
干预措施: Muscle Relaxant (Drug)
Bilateral quadratus lumborum block
Patients will receive Ultrasound-guided bilateral quadratus lumborum block following induction of general anaesthesia
干预措施: Maintenance of general anaesthesia (Drug)
结局指标
主要结局
Postoperative 24 hours cumulative rescue morphine consumption
时间窗: For 24 hours after surgery
次要结局
- The duration of postoperative analgesia(For 24 hours after surgery)
- Postoperative pain score at rest(For 24 hours after surgery)
- Systolic blood pressure(For 28 hours after induction of anesthesia)
- Postoperative pain score on movement(For 24 hours after surgery)
- Heart rate(For 28 hours after induction of anesthesia)
- Degree of postoperative nausea and vomiting(For 24 hours after surgery)
- Pruritis(For 24 hours after surgery)
- Postoperative pain score on cough(For 24 hours after surgery)
- Diastolic blood pressure(For 28 hours after induction of anesthesia)
- Mean blood pressure(For 28 hours after induction of anesthesia)