Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Defining the neurophysiological conditions that are necessary for conscious experience.
研究概览
简要总结
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
详细描述
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy right-handed men
- •Aged 18-35
- •Non-smokers
- •No metallic implants
排除标准
- •Younger than 18 or over the age of 35.
结局指标
主要结局
Defining the neurophysiological conditions that are necessary for conscious experience.
时间窗: Immediate
次要结局
- Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia.(Immediate)