Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University of Wisconsin, Madison
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Defining the neurophysiological conditions that are necessary for conscious experience.
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain. The results of this study will help to identify the neurophysiological correlates of changes in conscious experience that occur during drug-induced sedation.
Detailed Description
In the proposed experiments cortical areas will be stimulated using low frequency, low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during wakefulness and during drug-induced responsive sedation and unresponsive sedation. Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate the temporal and spatial characteristics of evoked responses and induced rhythms over the cortex.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy right-handed men
- •Aged 18-35
- •Non-smokers
- •No metallic implants
Exclusion Criteria
- •Younger than 18 or over the age of 35.
Outcomes
Primary Outcomes
Defining the neurophysiological conditions that are necessary for conscious experience.
Time Frame: Immediate
Secondary Outcomes
- Understanding the neurophysiological correlates of conditions associated with restricted conscious experience such as sedation and anesthesia.(Immediate)