High Frequency Jet Ventilation Versus Conventional Positive Pressure Ventilation for EBUS

Completed

• Conditions: Ultrasonography, Interventional; Intermittent Positive-Pressure Ventilation; High-Frequency Jet Ventilation
• Interventions: Procedure: Ventilation type

• Registration Number: NCT06537388
• Lead Sponsor: Erasme University Hospital

Brief Summary

Endobronchial ultrasound (EBUS) is frequently used in pneumology for diagnostic procedures like mediastinal biopsies. This procedure is usually done under general anesthesia. Different methods of ventilation are used according to center and physician preferences. In this retrospective study, complications of 2 types of ventilation will be analyzed:

* High frequency jet ventilation (HFJV)

* Conventional intermittent positive pressure ventilation (IPPV) Descriptive statistics will be used to present the data. Both ventilation techniques will be compared after propensity score matching. For HFJV patients from 2019 will be analyzed and for IPPV patients from 2023, as the team changed its practice over time.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-08-01
• Study First Submitted QC: 2024-08-01
• Study First Posted: 2024-08-05
• Study Start: 2024-08-15
• Primary Completion: 2025-03-30
• Status Verified: 2025-05
• Study Completion: 2025-05-01
• Last Update Submitted: 2025-05-20
• Last Update Posted: 2025-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 428

Inclusion Criteria

• All patients who underwent EBUS at Erasme University Hospital using either HFJV or IPPV between january 1st 2019 and december 31st 2019 or january 1st 2023 and december 31st 2023.

Exclusion Criteria

• Incomplete medical chart
• Patients who expressed an opposition to the use of their medical data
• Age < 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
EBUS_cohort	Ventilation type	All patients who underwent EBUS between January 1st 2019 and december 31st 2019 or January 1st 2023 and december 31st 2023 at Erasme University Hospital

Primary Outcome Measures

Name	Time	Method
Hypoxia	24 hours	defined as an SpO2 \< 90% for more than 1 min
Severe hypoxia	24 hours	defined as an SpO2 (oxygen saturation by pulse oximetry) \< 85% for more than 1 min
Hemodynamic instability	24 hours	defined as a systolic arterial blood pressure \< 90/60 mm Hg
Cardiac arrythmia	24 hours	Any cardiac rhythm other than sinus rhythm
Laryngospasm	24 hours	Any occurence of laryngospasm
ICU admission	24 hours	Necessity for admission to the intensive care unit (ICU)

Trial Locations

Locations (1)

Hôpital Universitaire de Bruxelles - Hôpital erasme; 🇧🇪 Brussels, Belgium