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临床试验/NCT03035981
NCT03035981已完成不适用

Assessment of Gastric Emptying and Fullness of Rice With Different Starch Properties

Purdue University0 个研究点目标入组 12 人开始时间: 2014年8月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
12
主要终点
Appetitive response

研究概览

简要总结

Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.

详细描述

Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Other
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 50 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

排除标准

  • •Under any medication
  • •History of any gastrointestinal disease or surgery

研究组 & 干预措施

White rice, low amylose

Experimental

Cooked white rice with low amylose content

干预措施: White rice, low amylose (Other)

White rice, high amylose

Experimental

Cooked white rice with high amylose content

干预措施: White rice, high amylose (Other)

White rice, slow

Experimental

Cooked white rice with slow digesting starch

干预措施: White rice, slow (Other)

White rice, resistant

Experimental

Cooked white rice with resistant starch

干预措施: White rice, resistant (Other)

Brown rice, low amylose

Experimental

Cooked brown rice with low amylose content

干预措施: Brown rice, low amylose (Other)

Brown rice, high amylose

Experimental

Cooked brown rice with high amylose content

干预措施: Brown rice, high amylose (Other)

Fructooligosaccharide (FOS)

Experimental

Fermentable carbohydrate solution

干预措施: Fructooligosaccharide (FOS) (Other)

结局指标

主要结局

Appetitive response

时间窗: Acute study, 4 hours after consumption of test food

Fullness and hunger questionnaire was given at various time points after consumption of test foods

Gastric emptying

时间窗: Acute study, 4 hours after consumption of test food

Breath test was performed using 13C-octanoic acid mixed into test meals

次要结局

  • Breath hydrogen(Acute study, 4 hours after consumption of test food)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bruce R. Hamaker

Professor

Purdue University

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