Assessment of Gastric Emptying and Fullness of Rice With Different Starch Properties
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 主要终点
- Appetitive response
研究概览
简要总结
Glycemic carbohydrates are associated with metabolic disturbances, such as type II diabetes, due to rapid digestion of starch into glucose. The specific properties of starch within these foods has been studied for the purpose of slowing their digestion rate and improving related physiological outcomes, such as gastric emptying rate. The current study investigated the relationship among starch digestion, gastric emptying rate and satiety in white and brown rice.
详细描述
Studies have indicated that starch-based foods with somewhat high amylose content have slower in vitro starch digestion rates, which relate to a low glycemic response. Low glycemic response is associated with delayed gastric emptying rate as well. Therefore, we hypothesized that rice with a slow starch digesting property would delay gastric emptying. White and brown rice with varying amylose contents were used in this study. A 13C-labeled octanoic acid breath test method was used to measure gastric emptying rate, and questionnaires were used to assess hunger and fullness during the testing sessions. Twelve healthy volunteers were recruited to participate in a crossover design study with six rice treatments and outcome measurements were gastric emptying and satiety assessments. One fermentable carbohydrate (fructooligosaccharide, FOS) solution was used to validate the production of breath hydrogen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)
排除标准
- •Under any medication
- •History of any gastrointestinal disease or surgery
研究组 & 干预措施
White rice, low amylose
Cooked white rice with low amylose content
干预措施: White rice, low amylose (Other)
White rice, high amylose
Cooked white rice with high amylose content
干预措施: White rice, high amylose (Other)
White rice, slow
Cooked white rice with slow digesting starch
干预措施: White rice, slow (Other)
White rice, resistant
Cooked white rice with resistant starch
干预措施: White rice, resistant (Other)
Brown rice, low amylose
Cooked brown rice with low amylose content
干预措施: Brown rice, low amylose (Other)
Brown rice, high amylose
Cooked brown rice with high amylose content
干预措施: Brown rice, high amylose (Other)
Fructooligosaccharide (FOS)
Fermentable carbohydrate solution
干预措施: Fructooligosaccharide (FOS) (Other)
结局指标
主要结局
Appetitive response
时间窗: Acute study, 4 hours after consumption of test food
Fullness and hunger questionnaire was given at various time points after consumption of test foods
Gastric emptying
时间窗: Acute study, 4 hours after consumption of test food
Breath test was performed using 13C-octanoic acid mixed into test meals
次要结局
- Breath hydrogen(Acute study, 4 hours after consumption of test food)
研究者
Bruce R. Hamaker
Professor
Purdue University
