Surfactant are alveolar surface reducing agents,used in preterm baby having lower pool surfactant i.e. respiratory distress syndrome. Sedation and pain reducing drug administration during surfactant therapy by less invasive technique will be assessed in this trial.

Not yet recruiting

Brief Summary: For all nonemergent neonatal ventilation,premedicarion is considered mandatory.Awake laryngoscopy is known to be painful and associated with many adverse events.There is still no concensus on whether or not to use sedation during LISA. With sedation LISA procedure become smooth and sucessful but it might compromise the infants respiratory drive which is a prerequisite for LISA. This study will therefore be conducted to determine the efeects of fentanyl on the requirement of mechanical ventilation in the 72hr following the procedure in infants with RDS.

Recruitment & Eligibility

Inclusion Criteria

Preterm baby with gestational age between 28 to 34 weeks diagnosed with RDS will enroll in this study .
RDS will be diagnosed clinically initially and later confirm by chest X ray .
A written informed consent will be obtained from the parents of the baby for participation in the study.

Exclusion Criteria

Primary Outcome Measures

Name	Time	Method
The primary outcome is the need for mechanical ventilation from the LISA procedure onwards up to 72 h of life.	The primary outcome is the need for mechanical ventilation from the LISA procedure onwards up to 72 h of life.

Secondary Outcome Measures

Name	Time	Method
Number of laryngoscopy attempts during the procedure	Complications occurring during and after the procedure SpO2 80 percentage hypotension with mean below gestational age bradycardia 100 bpm

Locations (1): evel III Neonatal Care Unit Department of Neonatology IPGMER SSKM HOSPITAL
🇮🇳
Kolkata, WEST BENGAL, India
evel III Neonatal Care Unit Department of Neonatology IPGMER SSKM HOSPITAL
🇮🇳Kolkata, WEST BENGAL, India
Dr Bijan Saha
Principal investigator
09051389120
bijansaha18@gmail.com