Use of silver nanoparticles for the treatment of pyorrhea

Phase 3

Not yet recruiting

• Conditions: Chronic periodontitis,

• Registration Number: CTRI/2019/04/018718
• Lead Sponsor: Research Cell KGMU

Brief Summary

25 patients with chronic periodontitis will be recruited for the study. A split mouth randomized study will be conducted where the drug will be given in one quadrant of the patient’s mouth along with scaling and root planning and the contralateral side will be treated with scaling and root planing along with pacebo. The patients will be selected in such a way that both sides of the mouth are equally affected by chronic periodontits.  The patient’s Gingival index, papillary bleeding index, probing pocket depth and clinical attachment gain will be recoreded at baseline, 1 month and then 3 months.

The patient’s gingival crevicular fluid will be collected at baseline,1 month and 3 months for its biochemical assay in order to assess the change in the level of interleukin 1 beta. The drug will be delivered in the periodontal pocket. This will be done in order to understand the clinical as well as the anti-inflammatory action of silver nanoparticles. If the outcome of the study will be positive it will be ascertained that Silver nanoparticles aid scaling and root planing in the treatment of chronic periodontitis.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-04-18
• Study Start: 2019-04-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1.25-50 years of age 2.Probing pocket depth ≥ 5mm 3.Systemically healthy patients 4.No history of periodontal therapy in the last 6 months.

Exclusion Criteria

• Pregnant or lactating women 3.
• Allergic to silver metal.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Use of Silver nanoparticles as an adjunct to scaling and root planing	1 month

Secondary Outcome Measures

Name	Time	Method
Use of Silver nanoparticles as an adjunct to scaling and root planing	3 months

Trial Locations

Locations (1)

King George Medical University; 🇮🇳 Lucknow, UTTAR PRADESH, India

King George Medical University

🇮🇳Lucknow, UTTAR PRADESH, India

Dr Ishita Joshi

Principal investigator

8851928717

ijoshi7@gmail.com