The Clinical and Anti-inflammatory action of Silver Nanoparticles in the treatment of Chronic Periodontitis
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Use of Silver nanoparticles as an adjunct to scaling and root planing
研究概览
简要总结
25 patients with chronic periodontitis will be recruited for the study. A split mouth randomized study will be conducted where the drug will be given in one quadrant of the patient’s mouth along with scaling and root planning and the contralateral side will be treated with scaling and root planing along with pacebo. The patients will be selected in such a way that both sides of the mouth are equally affected by chronic periodontits. The patient’s Gingival index, papillary bleeding index, probing pocket depth and clinical attachment gain will be recoreded at baseline, 1 month and then 3 months.
The patient’s gingival crevicular fluid will be collected at baseline,1 month and 3 months for its biochemical assay in order to assess the change in the level of interleukin 1 beta. The drug will be delivered in the periodontal pocket. This will be done in order to understand the clinical as well as the anti-inflammatory action of silver nanoparticles. If the outcome of the study will be positive it will be ascertained that Silver nanoparticles aid scaling and root planing in the treatment of chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.25-50 years of age 2.Probing pocket depth ≥ 5mm 3.Systemically healthy patients 4.No history of periodontal therapy in the last 6 months.
排除标准
- •Pregnant or lactating women
- •Allergic to silver metal.
结局指标
主要结局
Use of Silver nanoparticles as an adjunct to scaling and root planing
时间窗: 1 month
次要结局
- Use of Silver nanoparticles as an adjunct to scaling and root planing(3 months)