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Clinical Trials/NL-OMON28307
NL-OMON28307Not yet recruitingNot Applicable

Continuous positive airway pressure in severe Covid-19 pneumonia: a feasibility and physiological end-point study

Raad van Bestuur van het AMC (Amsterdam)0 sites13 target enrollmentStarted: TBDLast updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Enrollment
13

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional

Eligibility Criteria

Inclusion Criteria

  • •A subject must meet all of the following criteria:
  • •- age > 18 years
  • •- Positive for Covid-19 (CORADS 5, i.e. highly likely Covid-19 on the low-dose CT scan, or PCR positive nasopharyngeal swab for SARS Coronavirus 2).
  • •- Admitted to Amsterdam UMC, location AMC.
  • •- A transcutaneous O2 saturation (SpO2) of 90% or less at 5 l/min oxygen administration via nasal canula.
  • •- Provide informed consent.

Exclusion Criteria

  • •-Hypercapnia (defined as arterial PCO2 > 6.0 kPa or 45 mmHg)
  • •-A history of moderate to severe Chronic Obstructive Pulmonary Disease (COPD, GOLD severity III or IV), restrictive lung disease, or Obesity Hypoventilation Syndrome
  • •-Need for intubation or admission to the Intensive Care Unit as determined by the responsible physician
  • •-Palliative care
  • •-Reduced consciousness
  • •-Unability to wear the mask due to anatomical / physical restriction (e.g. facial operations; bearded)
  • •-Unable to provide informed consent.

Investigators

Sponsor
Raad van Bestuur van het AMC (Amsterdam)

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