Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

Completed

• Conditions: Proteinosis; Postoperative Complications
• Interventions: Procedure: The left colonic artery is not preserved; Procedure: Preserve the left colonic artery

• Registration Number: NCT03776370
• Lead Sponsor: Third Military Medical University

Brief Summary

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Detailed Description

The investigators performed three-dimensional (3D) reconstruction to investigate the vascular anatomy, including the inferior mesenteric artery (IMA) and left colic artery (LCA),to help make pre-operative strategies of rectal cancer surgery.The investigators will preserving the left colonic artery during rectal cancer surgery and evaluate its feasibility and clinical significance.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Study Timeline

• Study Start: 2018-12-01
• Study First Submitted: 2018-12-09
• Study First Submitted QC: 2018-12-11
• Study First Posted: 2018-12-14
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-01
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-28
• Last Update Posted: 2022-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Pathological biopsy confirmed adenocarcinoma of the rectum；
2. Preoperative assessment of tolerance to surgery without major organ dysfunction；
3. Patients must be able to understand and voluntarily sign written informed consent；
4. The surgical method is laparoscopic or robotic anterior rectal cancer resection.

Exclusion Criteria

1. The patient cannot tolerate the operation；
2. Refusal to sign informed consent；
3. Patients with distant metastasis of rectal cancer；
4. The surgical method was changed to miles or Hartman;
5. Unable to complete the follow - up

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
The left colonic artery is not preserved	The left colonic artery is not preserved	The left colonic artery was dissected in rectal cancer surgery
Preserve the left colonic artery	Preserve the left colonic artery	Preservation of left colonic artery in rectal cancer surgery.

Primary Outcome Measures

Name	Time	Method
The incidence of postoperative anastomotic leakage was compared between the two groups.	Within 30 days after surgery	The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group.
The distant metastasis rates of rectal cancer between the two groups were compared.	Two years after surgery	The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group.
The five-year survival rates of rectal cancer between the two groups were compared.	Five years after surgery	The 5-year survival rates of rectal cancer in the intervention group and the control group were compared.
The local recurrence rates of rectal cancer between the two groups were compared.	Two years after surgery	The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group.

Trial Locations

Locations (1)

zongming,Kang; 🇨🇳 Yuzhong, Chongqing, China