Effects of Inferior Mesenteric Artery Preservation in Laparoscopic Colorectal Resection for Diverticular Disease.
- Conditions
- Colonic Diverticuar DiseaseDefecatory FunctionsFecal IncontinenceConstipation
- Registration Number
- NCT06506552
- Lead Sponsor
- University of Roma La Sapienza
- Brief Summary
This is a prospective randomized study aimed to verifying the short and long-term results of inferior mesenteric artery preservation following colorectal resection for diverticular disease
- Detailed Description
This study wants to demonstrate that the preservation of the inferior mesenteric artery allow to improve postoperative defecatory function and improve patient\'s quality of life.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 300
- BMI < 35
- ASA I-III
- Hinchey I-III
- BMI > 35
- ASA IV
- Hinchey IV
- Previous procedures that could have been modified the nervous mesenteric pattern (surgery, radiotherapy or chemotherapy)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Defecatory disorders 6 years from surgery the presence of defecatory disorders was evaluated (Costipation, Evacuation frequency,evacuation urgency, fragmented evacuation,flatus incontinence, liquid incontinence)
- Secondary Outcome Measures
Name Time Method Postoperative surgical complication 1 month from surgery The incidence of postoperative surgical complications was evaluated
Constipation 6 years from surgery The incidence and severity of postoperative constipation was evaluated with Cleveland Clinic Constipation Score ( score range from 0 to 30, the higher score defines worse constipation status)
Incontinence 6 years from surgery The presence of fecal incontinence was evaluated with Cleveland Clinic Incontinence Score( score ranges from 0 to 20, the higher score defines worse symptoms)
Anorectal Muscles function 6 years from surgery the anorectal muscles function was evaluated with anorectal manometry ( sphincter lenght, maximum squeeze pression, resting anal pressure, squeeze duration, maximum pressure sustained)
Postoperative quality of life 6 years from surgery The postoperative QOL was evaluated with SF-36 score (Short form-36 score, each item scored from 0 to 100, the higher scores defines a favorable health state)