A prospective study to determine the prevalence of HCV infection among family members of HCV infected patients and also to analyze Intrafamilial correlations in Hepatitis C Virus (HCV).
- Registration Number
- CTRI/2010/091/001231
- Lead Sponsor
- Investigator sponsored Dr. Ajit Sood
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 100
1. Index patients with serologically confirmed Hepatitis-C viral infection
2. Family members of Index Patients with age above 5 years, staying together in same house
3. Written informed consent from adult family members (age ≥ 18 years) and assent from pediatric members in addition for participation in the study
4. Control Patients with serological evidence of Hepatitis C without any family members infected with Hepatitis C
5. Willing to provide feedback on questionnaire for identifying risk factors
6. Willing to provide blood sample for serological analysis and other laboratory analysis
1. Index Patients, their Family members and Control patients who have been treated with Interferon based therapy and already cleared of virus.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To evaluate the Genotype and HCV sequencing (Phylogenetic analysis) of the virus affecting the family members <br>2. To determine the prevalence of HCV infection among family members of Index patients with HCV infection <br>Timepoint: 4 Months for field visits, completion of questionnaire and collection of samples / results.
- Secondary Outcome Measures
Name Time Method 1. To identify the factors responsible for intrafamilial spread of HCV infection.<br>2. To determine phylogenetic similarity between Index patients and their infected Neighbours with no evidence of familial prevalence<br>Timepoint: 4 Months for field visits, completion of questionnaire and collection of samples / results