Measure the Serum Level of Homocysteine in Acne Patients Before and After Oral Isotretinoin.

Phase 4

Completed

• Conditions: Acne Vulgaris
• Interventions: Drug: Isotretinoin

• Registration Number: NCT05529888
• Lead Sponsor: Aswan University

Brief Summary

Serum homocysteine level in Acne patients before and after oral Isotretinoin and Correlation between serum level of homocysteine in acne patients before and after Oral isotretinoin treatment

Detailed Description

Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms tha...

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2020-12-15
• Primary Completion: 2021-12-15
• Study Completion: 2021-12-15
• Status Verified: 2022-09
• Study First Submitted: 2022-09-01
• Study First Submitted QC: 2022-09-03
• Last Update Submitted: 2022-09-03
• Study First Posted: 2022-09-07
• Last Update Posted: 2022-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients of both sexes with acne vulgaris

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Exclusion Criteria

• Patients with history of malignancies.
• Patients with renal and hepatic dysfunction.
• Cardiac patient.
• Pregnant, lactating and female welling to have pregnancy in the period of study.
• Patient with absorption disorder.
• Patient with history of favism.
• Patient has already been treated with isotretinoin.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patient group	Isotretinoin	Patients were treated with Isotretinoin in a dose (from 20 to 40) for 3 months and serum homocysteine were assessed before and after treatment

Primary Outcome Measures

Name	Time	Method
Evaluation of the effect of oral isotretinoin on Serum homocysteine in acne vulgaris patients	3 months	Assessment in serum level homocysteine level in acne vulgaris patients after isotretinoin therapy with assesment of its level before starting therapy for detecting changes in serum homocysteine and effect of isotretinoin therapy on it.

Trial Locations

Locations (1)

Aswan University-Faculty of Medicine; 🇪🇬 Aswan, New Aswan City, Egypt