Serum Homocysteine Level in Acne Patients Before and After Oral Isotretinoin
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Evaluation of the effect of oral isotretinoin on Serum homocysteine in acne vulgaris patients
研究概览
简要总结
Serum homocysteine level in Acne patients before and after oral Isotretinoin and Correlation between serum level of homocysteine in acne patients before and after Oral isotretinoin treatment
详细描述
Acne vulgaris is a common chronic inflammatory disease of the skin. It is found in about 80% of young adults and adolescents. It is a disease that affects the pilosebaceous units of the skin and may result in inflammatory or non-inflammatory lesions,Oral isotretinoin (13-cis-retinoic acid) is the only drug that counteracts all the pathogenetic mechanisms that contribute to the development of acne The standard dose of isotretinoin is 0.5 to 1 mg/kg per day for 4 months to a cumulative dose of 120-140 mg/kg is effective in the management of acne vulgaris The scope of our study is to detect serum homocysteine level in acne patient befor and after oral isotrtinoin treatment
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients of both sexes with acne vulgaris
排除标准
- •Patients with history of malignancies.
- •Patients with renal and hepatic dysfunction.
- •Cardiac patient.
- •Pregnant, lactating and female welling to have pregnancy in the period of study.
- •Patient with absorption disorder.
- •Patient with history of favism.
- •Patient has already been treated with isotretinoin.
研究组 & 干预措施
Patient group
Patients were treated with Isotretinoin in a dose (from 20 to 40) for 3 months and serum homocysteine were assessed before and after treatment
干预措施: Isotretinoin (Drug)
结局指标
主要结局
Evaluation of the effect of oral isotretinoin on Serum homocysteine in acne vulgaris patients
时间窗: 3 months
Assessment in serum level homocysteine level in acne vulgaris patients after isotretinoin therapy with assesment of its level before starting therapy for detecting changes in serum homocysteine and effect of isotretinoin therapy on it.
次要结局
未报告次要终点
研究者
Doaa Hamdi Abd Elal Mohamed
Principal Investigator
Aswan University