Body Weight Growth After Birth and Bronchopulmonary Dysplasia

Withdrawn

• Conditions: Bronchopulmonary Dysplasia; Preterm
• Interventions: Other: good body weight growth; Other: poor body weight growth

• Registration Number: NCT05053269
• Lead Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Brief Summary

Bronchopulmonary dysplasia (BPD) is one of the most common, complex, and severe diseases in preterm infants. BPD was first described as chronic pulmonary disease in survivors of severe respiratory distress syndrome (RDS) in 1967, which was also called as the "old" BPD. In recent years, the definition for BPD has developed a lot. The National Institute of Child Health and Human Development (NICHD) workshop in 2018 assessed BPD at 36 post-menstrual age (PMA) along with radiographic confirmation and used a severity grading of I-III. Although with effective surfactant supplement and oxygen support, BPD brings a great challenge to neonatologists.

Detailed Description

Besides persistent inflammation, prolonged invasive ventilation and oxidative damage. body weight is the one of the most important factors to induce BPD. Poor extrauterine growth is commonly described in extremely preterm infants. But, the relationship of postnatal growth with BPD and respiratory morbidity is not entirely understood.

The aim of the present study is to assess whether body weight growth after birth is the risk factor for BPD.

Study Timeline

• Study First Submitted: 2021-09-12
• Study First Submitted QC: 2021-09-15
• Study First Posted: 2021-09-22
• Study Start: 2021-10-01
• Status Verified: 2022-10
• Last Update Submitted: 2023-04-28
• Last Update Posted: 2023-05-01
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• equal to or less than 32 weeks' gestational age

Exclusion Criteria

• main congenital malformation
• parents' refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
good body weight growth	good body weight growth	body weight growth after birth is consistent with the growth curve
poor body weight growth	poor body weight growth	body weight growth after birth is inconsistent with the growth curve

Primary Outcome Measures

Name	Time	Method
the incidence of BPD	up to 36 weeks' gestational age	the infant was diagnosed with BPD

Secondary Outcome Measures

Name	Time	Method
body weight growth after birth	up to 36 weeks' gestational age	to assess whether body weight growth after birth is consistent with the growth curve

Trial Locations

Locations (1)

Children's Hospital of Chongqing Medical University; 🇨🇳 Chongqing, Chongqing, China