Assessing brain hemodynamics using Arterial Spin Labeling MRI.
Withdrawn
- Conditions
- Cerebrovascular diseasestroke10003216
- Registration Number
- NL-OMON35194
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
(p. 15 protocol)
> 18 year
informed consent
Intracranial occlusion
Extracranial occlusion
Extracranial stenosis
In stroke patients, MRI scan within one week of symptom onset
Exclusion Criteria
(p.15 protocol)
Contraindications for MRI (claustrophobia, or standard MRI contraindications such as pacemakers or specific metal objects in or around the body)
Unwilling or unable to co-operate with breathing manoeuvres
Respiratory or cardiac limitations to breathing at 20L/min
Medical contra-indications to limited hypercapnia (known increased intracerebral pressure, metabolic acidosis or alkalosis)
Altered consciousness
Non compliance with prescribed anti-seizure medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our objective is to test the feasibility of the application of a CO2-challenge<br /><br>to measure Cerebrovascular Reactivity in healthy subjects and in<br /><br>cerebrovascular diseased patients with Arterial Spin Labeling MRI and to test<br /><br>the feasibility of a Velocity-Selective Spin Labeling sequence to measure the<br /><br>Cerebral Metabolic Rate of Oxygen. </p><br>
- Secondary Outcome Measures
Name Time Method <p>To obtain baseline values of these two parameters in a healthy control group<br /><br>and in patients with cerebrovascular disease.</p><br>