Thyroid Function in Late Preterm Infants in Relation to Severity of Illness

Christiana Care Health Services1 site in 1 country150 target enrollmentSeptember 2009

ConditionsTransient Hypothyroxinemia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Transient Hypothyroxinemia
Sponsor: Christiana Care Health Services
Enrollment: 150
Locations: 1
Primary Endpoint: Correlation of total T4 and TSH with gestational age, birth weight, and mode of delivery.
Status: Completed
Last Updated: 15 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Transient hypothyroxinemia (TH) is a condition characterized by low levels of serum thyroxine (T4) and normal levels of thyroid stimulating hormone (TSH). TH in premature infants has been found to be related to severity of illness. T4 levels in very low birth weight infants born prematurely has been found to be inversely correlated to severity of illness. In very low birth weight infants, TH has been associated with poor outcomes. Little is known about thyroid function in late preterm infants.

Hypotheses:

Ill late preterm infants will have lower total T4 levels than healthy late preterm infants.
Total T4 and possibly TSH levels will be inversely correlated with short-term outcomes.
Late Preterm infants born by cesarean section will have lower T4 levels compared to those born by vaginal birth.

Registry

clinicaltrials.gov

Start Date

September 2009

End Date

January 2011

Last Updated

15 years ago

Study Type

Observational

Sex

All