Prevalence of Hepatitis C Virus Infection in HIV-Infected Children
- Conditions
- HIV InfectionsHepatitis C
- Registration Number
- NCT00037076
- Brief Summary
The purpose of this study is to find out how many children who are infected with HIV are also infected with hepatitis C virus (HCV).
HCV infection is a major health concern. HIV-infected adults who are co-infected with HCV appear to have more rapid HIV disease progression. There is little data on how widespread HCV is among children who are HIV-infected. Information from this study will help determine the need for future HCV studies. This study also will obtain blood samples for future testing for other hepatitis viruses such as hepatitis G virus (HGV or GB virus C).
- Detailed Description
HCV infection is a major public health concern with worldwide seroprevalence estimated at 1 percent. HIV-infected adults co-infected with HCV appear to have accelerated HIV disease progression. There is little data on HCV prevalence in the pediatric HIV-infected population. This substudy will provide estimates of HCV prevalence among HIV-infected children and determine the need for future HCV natural history and treatment protocols. In addition, this substudy will archive samples from patients for future testing for other hepatitis viruses such as hepatitis G virus (HGV or GB virus C).
Patients participating in PACTG 219C are selected randomly to enroll into PACTG P1028S. Patients who agree to participate have a single blood draw for HCV antibody (Enzyme Immunoassay-EIA) testing and HCV RNA (Polymerase Chain Reaction-PCR) testing. An additional blood draw is necessary in the case of discordant results between the HCV EIA and HCV PCR. HCV-negative patients have 1 study visit. Patients with positive HCV test results have 2 visits. Patients with discordant HCV test results have 2 or 3 visits.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 600
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (39)
Mt Sinai Hosp Med Ctr / Dept of Pediatrics
🇺🇸Chicago, Illinois, United States
Saint Jude Children's Research Hosp of Memphis
🇺🇸Memphis, Tennessee, United States
Univ of California, San Diego
🇺🇸San Diego, California, United States
Univ of Miami (Pediatric)
🇺🇸Miami, Florida, United States
Texas Children's Hosp / Baylor Univ
🇺🇸Houston, Texas, United States
UCSF, Moffitt Hospital (Pediatric)
🇺🇸San Francisco, California, United States
Vanderbilt Univ Med Ctr
🇺🇸Nashville, Tennessee, United States
Childrens Hosp of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Children's Med Ctr of Dallas
🇺🇸Dallas, Texas, United States
Duke University (Pediatric)
🇺🇸Durham, North Carolina, United States
Univ of Maryland at Baltimore / Univ Med Ctr
🇺🇸Baltimore, Maryland, United States
Mount Sinai Med Ctr
🇺🇸New York, New York, United States
Baystate Med Ctr of Springfield
🇺🇸Springfield, Massachusetts, United States
Columbia Presbyterian Med Ctr
🇺🇸New York, New York, United States
Children's Hospital at SUNY Downstate
🇺🇸Brooklyn, New York, United States
The Univ of Chicago Children's Hosp
🇺🇸Chicago, Illinois, United States
Tulane Univ / Charity Hosp of New Orleans
🇺🇸New Orleans, Louisiana, United States
Univ of Rochester Med Ctr
🇺🇸Rochester, New York, United States
Johns Hopkins Hosp - Pediatric
🇺🇸Baltimore, Maryland, United States
Univ of Medicine & Dentistry of New Jersey / Univ Hosp
🇺🇸Newark, New Jersey, United States
State Univ of New York at Stony Brook
🇺🇸Stony Brook, New York, United States
University of Illinois
🇺🇸Chicago, Illinois, United States
Univ. of Puerto Rico, U. Children's Hospital AIDS
🇵🇷San Juan, Puerto Rico
Univ of Massachusetts Med School
🇺🇸Worcester, Massachusetts, United States
San Juan City Hosp
🇵🇷San Juan, Puerto Rico
SUNY Health Sciences Ctr at Syracuse / Pediatrics
🇺🇸Syracuse, New York, United States
St. Christopher's Hosp for Children, Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Univ of Alabama at Birmingham - Pediatric
🇺🇸Birmingham, Alabama, United States
Children's Hosp of Denver
🇺🇸Denver, Colorado, United States
Children's Hosp of Michigan
🇺🇸Detroit, Michigan, United States
Phoenix Childrens Hosp
🇺🇸Phoenix, Arizona, United States
Los Angeles County - USC Med Ctr
🇺🇸Los Angeles, California, United States
Children's Hosp of Oakland
🇺🇸Oakland, California, United States
Howard Univ Hosp
🇺🇸Washington, District of Columbia, United States
Yale Univ Med School
🇺🇸New Haven, Connecticut, United States
Connecticut Childrens Med Ctr (Pediatric)
🇺🇸Farmington, Connecticut, United States
The Med Ctr Inc
🇺🇸Columbus, Georgia, United States
Med College of Georgia
🇺🇸Augusta, Georgia, United States
Univ of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States