Usak University Faculty of Dentistry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Periodontitis
- Sponsor
- Uşak University
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- It was aimed to compare IL-34 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups.
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim of this study to investigate GCF levels of IL-34 and CSF-1 in periodontitis subjects with diabetes.
Detailed Description
Periodontally healthy (H), periodontitis, and periodontitis with diabetes patients, were recruited for this study. 1. Inclusion criteria for H groups: Individuals with clinically healthy gingiva, no attachment and bone loss, and less than 10% bleeding on probing were included. 2. Inclusion criteria for periodontitis groups: Systemically healthy individuals with interdental CAL ≥ 5 mm and PPD ≥ 6 mm were included. 3. Inclusion criteria for periodontitis with diabetes groups: Type 2 diabetes patients with interdental CAL ≥ 5 mm, PPD ≥ 6 mm, and HbA1c ≥ 6.5% were included. The plaque index (PI), gingival index (GI), presence of bleeding on probing (BOP), PD, and clinical AL were used for clinical periodontal assessments. All assessments were done with a manual probe. GCF samples were obtained and analyzed using an enzyme-linked immunosorbent assay.
Investigators
Eligibility Criteria
Inclusion Criteria
- •have 20 teeth
- •have diabetes .
Exclusion Criteria
- •Individuals have systemic disease
- •those using drugs;
Outcomes
Primary Outcomes
It was aimed to compare IL-34 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups.
Time Frame: GCF samples taken within the 1. week after the clinical examination of the patient
GCF was taken interproximal region.
Secondary Outcomes
- It was aimed to compare CSF-1 levels by taking gingival crevicular fluid in systemic healthy, periodontitis and diabetic patients with periodontitis groups.(GCF samples taken within the 1. week after the clinical examination of the patient)