Cross-sectional study of the characteristics of arthropathy in long-term well-controlled acromegalic patients

Completed

• Conditions: joint problems in acromegaly (acromegalia); 10021112; 10023213

• Registration Number: NL-OMON30077
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

- Informed consent.
- All patients treated for acromegaly by surgery, radiotherapy and medical treatment and followed at the Dept of Endocrinology with control of disease activity defined as a normal IGF-I for age and/ or a normal glucose-induced GH suppression.
- Appropriate hormonal substitution of dysfunctional hormonal axes.

Exclusion Criteria

- Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-clinical parameters: extensive physical examination<br /><br>-radiological parameters: knee, hands, hip and axial skeleton<br /><br>-functional parameters: assessment of hand/ shoulder/ lower extremity function<br /><br>-biochemical parameters: parameters of hormonal status/ inflammation/<br /><br>osteoarthritis<br /><br>-DNA: genes associated with predisposition of osteoarthritis and pituitary<br /><br>adenomas</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A.</p><br>