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临床试验/NCT01886989
NCT01886989已完成不适用

Postprandial Effects of Polyphenol-rich Cocoa Beverage on Glucose, Insulin, Lipids, Oxidative Stress and Inflammation in Type 2 Diabetic Patients

Arpita Basu2 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2012年1月最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
18
试验地点
2
主要终点
Blood pressure (mm Hg)

研究概览

简要总结

This study aims to investigate the postprandial effects of cocoa supplementation in glucose and lipids, and surrogate markers of atherosclerosis in patients with type 2 diabetes. The investigators aim to test the hypothesis that cocoa will lower high-fat mixed meal breakfast-induced postprandial rise of glucose, lipids and markers of atherosclerosis in patients with diabetes. Randomized cross-over controlled trial, in which participants will be assigned to the placebo or cocoa group with breakfast meal. Patients with type 2 diabetes(n=25) will qualify for the study. The participants will be asked to consume 2 cups cocoa or placebo beverage on 2 separate postprandial study days. Both groups will receive high-fat mixed meal breakfast on each day. Blood draws and blood pressure (including HDI) measurements will be conducted at fasting, 30 min, 1,2, 4 & 6 hours postprandial each day for 2 days.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
Single (Participant)

入排标准

年龄范围
21 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • clinical diagnosis of type 2diabetes

排除标准

  • on insulin therapy

研究组 & 干预措施

Cocoa

Experimental

Cocoa polyphenols (960mg)

干预措施: Cocoa polyphenols (Dietary Supplement)

Placebo

Placebo Comparator

Placebo powder (109mg polyphenols) in water

干预措施: Cocoa polyphenols (Dietary Supplement)

结局指标

主要结局

Blood pressure (mm Hg)

时间窗: 2.5 years

Change in blood pressure and vascular function following cocoa and placebo intervention

次要结局

  • Blood lipids(2.5 years)
  • Inflammation(2.5 years)
  • Glucose (mg/dL)(2.5 years)

研究者

发起方
Arpita Basu
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Arpita Basu

Associate Professor

Oklahoma State University

研究点 (2)

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